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Literature summary for 1.14.14.1 extracted from

  • Gewonyo, K.; Buckland, B.C.; Lilly, M.D.
    Development of a large-scale continuous substrate to feed process for the biotransformation of simvastatin by Nocardia sp. (1991), Biotechnol. Bioeng., 37, 1101-1107.
    View publication on PubMed

Application

Application Comment Organism
synthesis production of 6-beta-hydroxy-methyl-simvastatin, simvastatin and derivatives belong to the family of HMG-CoA reductase inhibitors, which are potent cholesterol-lowering therapeutic agents Pseudonocardia autotrophica

Organism

Organism UniProt Comment Textmining
Pseudonocardia autotrophica
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
simvastatin + [reduced NADPH-hemoprotein reductase] + O2
-
Pseudonocardia autotrophica 6-beta-hydroxy-methyl-simvastatin + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
27
-
-
Pseudonocardia autotrophica

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
-
Pseudonocardia autotrophica