Cloned (Comment) | Organism |
---|---|
both isozymes CYP52A13, CYP52A17 | Candida tropicalis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.023 | - |
myristic acid | isozyme CYP52A17, pH 7.4, 35°C | Candida tropicalis | |
0.075 | - |
oleic acid | isozyme CYP52A17, pH 7.4, 35°C | Candida tropicalis | |
0.084 | - |
oleic acid | isozyme CYP52A13, pH 7.4, 35°C | Candida tropicalis | |
0.11 | - |
myristic acid | isozyme CYP52A13, pH 7.4, 35°C | Candida tropicalis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Candida tropicalis | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Candida tropicalis | - |
ATCC 20336, isozymes CYP52A13, CYP52A17 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
decanoic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Candida tropicalis | ? + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
dodecanoic acid + [reduced NADPH-hemoprotein reductase] + O2 | isozyme CYP52A17, good substrate | Candida tropicalis | ? + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
eicosenoic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Candida tropicalis | ? + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
linoleic acid + [reduced NADPH-hemoprotein reductase] + O2 | isozyme CYP52A17, good substrate, isozyme CYP52A13, good substrate | Candida tropicalis | ? + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
myristic acid + [reduced NADPH-hemoprotein reductase] + O2 | isozyme CYP52A17, best substrate | Candida tropicalis | omega-hydroxy-myristic acid + [oxidized NADPH-hemoprotein reductase] + H2O | isoform CYP52A17, additional fornmation of about 15% dicarbonic acid | ? | |
oleic acid + [reduced NADPH-hemoprotein reductase] + O2 | isozyme CYP52A13, best substrate,isozyme CYP52A17, good substrate | Candida tropicalis | omega-hydroxy oleic acid + n-decan-dicarboxylic acid + [oxidized NADPH-hemoprotein reductase] + H2O | isozyme CYP52A13, products in ratio 1:1, CYP52A17, ratio 3:7 of hydroxy- and dicarboxy-product | ? | |
palmitic acid + [reduced NADPH-hemoprotein reductase] + O2 | isozyme CYP52A17, good substrate | Candida tropicalis | ? + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
stearic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Candida tropicalis | ? + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome P450 | - |
Candida tropicalis | |
NADPH | - |
Candida tropicalis |