Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-kynurenine + NADPH + O2 | Homo sapiens | function of the enzyme may change from a role in immunosuppression at the maternal-fetal interface in early pregnancy to one associated with regulation of fetoplacental blood flow or placental metabolism in late gestation | 3-hydroxy-L-kynurenine + NADP+ + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood vessel | villous, endothel | Homo sapiens | - |
endothelium | vascular, of villous blood vessels | Homo sapiens | - |
epithelium | placental | Homo sapiens | - |
macrophage | in first and second trimester of the placenta, within the fetal villus | Homo sapiens | - |
additional information | localization in placenta, overview | Homo sapiens | - |
placenta | especially in stromal and glandular epithelium in the first trimester decidua | Homo sapiens | - |
stromal cell | in first and second trimester of the placenta | Homo sapiens | - |
syncytiotrophoblast | in first and second trimester of the placenta | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-kynurenine + NADPH + O2 | - |
Homo sapiens | 3-hydroxy-L-kynurenine + NADP+ + H2O | - |
? | |
L-kynurenine + NADPH + O2 | function of the enzyme may change from a role in immunosuppression at the maternal-fetal interface in early pregnancy to one associated with regulation of fetoplacental blood flow or placental metabolism in late gestation | Homo sapiens | 3-hydroxy-L-kynurenine + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
KYN-OHase | - |
Homo sapiens |
kynurenine hydroxylase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |