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Literature summary for 1.14.13.9 extracted from

  • Giorgini, F.; Guidetti, P.; Nguyen, Q.; Bennett, S.C.; Muchowski, P.J.
    A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease (2005), Nat. Genet., 37, 526-531.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.13.9

Application

Application Comment Organism
medicine enzyme is a therapeutical target for treatment of Huntigton disease Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3,4-dimethoxy-N-[4-(3-nitrophenyl)thiazol-2-yl]benzenesulfonamide i.e. Ro 61-8048, high-affinity low molecular inhibitor Saccharomyces cerevisiae
Ro 61-8048 high-affinity low molecular inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-
mitochondrion
-
 Saccharomyces cerevisiae 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-kynurenine + NADPH + O2 Homo sapiens step in L-tryptophan catabolism, overview 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?
L-kynurenine + NADPH + O2 Saccharomyces cerevisiae step in L-tryptophan catabolism, overview 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?
additional information Homo sapiens the enzyme is a very potent suppressor of toxicity of a fragment of the protein huntingtin, Htt, which causes the neurodegenerative Huntington disease by aggregation in nuclear and cytoplasmic inclusion bodies ?
-
 ?
additional information Saccharomyces cerevisiae the enzyme is a very potent suppressor of toxicity of a fragment of the protein huntingtin, Htt, which causes the neurodegenerative Huntington disease in humans by aggregation in nuclear and cytoplasmic inclusion bodies ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Saccharomyces cerevisiae
-
 diverse strains
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-kynurenine + NADPH + O2
-
 Homo sapiens 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?
L-kynurenine + NADPH + O2
-
 Saccharomyces cerevisiae 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?
L-kynurenine + NADPH + O2 step in L-tryptophan catabolism, overview Homo sapiens 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?
L-kynurenine + NADPH + O2 step in L-tryptophan catabolism, overview Saccharomyces cerevisiae 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?
additional information the enzyme is a very potent suppressor of toxicity of a fragment of the protein huntingtin, Htt, which causes the neurodegenerative Huntington disease by aggregation in nuclear and cytoplasmic inclusion bodies Homo sapiens ?
-
 ?
additional information the enzyme is a very potent suppressor of toxicity of a fragment of the protein huntingtin, Htt, which causes the neurodegenerative Huntington disease in humans by aggregation in nuclear and cytoplasmic inclusion bodies Saccharomyces cerevisiae ?
-
 ?

Synonyms

Synonyms Comment Organism
Bna4
-
 Homo sapiens
Bna4
-
 Saccharomyces cerevisiae
KMO
-
 Homo sapiens
KMO
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens
NADPH
-
 Saccharomyces cerevisiae