Literature summary for 1.14.13.9 extracted from

Heidempergher, F.; Pevarello, P.; Pillan, A.; Pinciroli, V.; Torre, A.D.; Speciale, C.; Marconi, M.; Cini, M.; Toma, S.; Greco, F.; Varasi, M.
Pyrrolo[3,2-c]quinoline derivates: a new class of kynurenine-3-hydroxylase inhibitors (1999), Farmaco, 54, 152-160.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(m-nitrobenzoyl)-alanine	various pyrrolo[3,2-c]quinoline derivates cause enzyme inhibition	Rattus norvegicus
7-chloro-3-methyl-1H-pyrrolo[3,2-c]quinoline-4-carboxylic acid	relatively potent and selective inhibitor	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Rattus norvegicus	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-kynurenine + NADPH + O2	Rattus norvegicus	-	? + NADP+	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-kynurenine + NADPH + O2	-	Rattus norvegicus	? + NADP+	-	?

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Release 2023.1 (January 2023)