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Literature summary for 1.14.13.84 extracted from

  • Mihovilovic, M.D.; Kapitan, P.; Rydz, J.; Rudroff, F.; Ogink, F.H.; Fraaije, M.W.
    Biooxidation of ketones with a cyclobutanone structural motif by recombinant whole-cells expressing 4-hydroxyacetophenone monooxygenase (2005), J. Mol. Catal. B, 32, 135-140.
No PubMed abstract available

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli TOP10 Pseudomonas fluorescens
gene hapE, overexpression in Escherichia coli Pseudomonas fluorescens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(4-hydroxyphenyl)ethan-1-one + NADPH + O2 Pseudomonas fluorescens
-
4-hydroxyphenyl acetate + NADP+ + H2O
-
?
(4-hydroxyphenyl)ethan-1-one + NADPH + O2 Pseudomonas fluorescens ACB
-
4-hydroxyphenyl acetate + NADP+ + H2O
-
?

Organism

Organism UniProt Comment Textmining
Pseudomonas fluorescens
-
-
-
Pseudomonas fluorescens
-
gene hapE
-
Pseudomonas fluorescens ACB
-
-
-
Pseudomonas fluorescens ACB
-
gene hapE
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(4-hydroxyphenyl)ethan-1-one + NADPH + O2
-
Pseudomonas fluorescens 4-hydroxyphenyl acetate + NADP+ + H2O
-
?
(4-hydroxyphenyl)ethan-1-one + NADPH + O2 Baeyer-Villiger oxidation, stereospecific reaction, regioselectivity Pseudomonas fluorescens 4-hydroxyphenyl acetate + NADP+ + H2O
-
?
(4-hydroxyphenyl)ethan-1-one + NADPH + O2
-
Pseudomonas fluorescens ACB 4-hydroxyphenyl acetate + NADP+ + H2O
-
?
(4-hydroxyphenyl)ethan-1-one + NADPH + O2 Baeyer-Villiger oxidation, stereospecific reaction, regioselectivity Pseudomonas fluorescens ACB 4-hydroxyphenyl acetate + NADP+ + H2O
-
?
2-oxabicyclo[3.2.0]heptan-6-one + NADPH + O2
-
Pseudomonas fluorescens ?
-
?
2-oxabicyclo[3.2.0]heptan-6-one + NADPH + O2
-
Pseudomonas fluorescens ACB ?
-
?
2-oxabicyclo[4.2.0]octan-7-one + NADPH + O2
-
Pseudomonas fluorescens ?
-
?
3-oxabicyclo[3.2.0]heptan-6-one + NADPH + O2
-
Pseudomonas fluorescens ?
-
?
bicyclo[3.2.0]hept-2-en-6-one + NADPH + O2
-
Pseudomonas fluorescens ?
-
?
bicyclo[3.2.0]hept-2-en-6-one + NADPH + O2
-
Pseudomonas fluorescens ACB ?
-
?
bicyclo[3.2.0]heptan-6-one + NADPH + O2
-
Pseudomonas fluorescens ?
-
?
bicyclo[4.2.0]octan-7-one + NADPH + O2
-
Pseudomonas fluorescens ?
-
?
additional information substrate specificity, regioselectivity, the enzyme preferably and stereospecifically catalyzes Baeyer-Villiger oxidations of of ketones bearing a cyclobutanone structural motif, e.g. oxidation of several prochiral cyclobutanones to antipodal butyrolactones, overview Pseudomonas fluorescens ?
-
?
additional information substrate specificity, regioselectivity, the enzyme preferably and stereospecifically catalyzes Baeyer-Villiger oxidations of of ketones bearing a cyclobutanone structural motif, e.g. oxidation of several prochiral cyclobutanones to antipodal butyrolactones, overview Pseudomonas fluorescens ACB ?
-
?
tricyclo[4.2.1.02,5]nonan-3-one + NADPH + O2
-
Pseudomonas fluorescens ?
-
?

Synonyms

Synonyms Comment Organism
HAPMO
-
Pseudomonas fluorescens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Pseudomonas fluorescens
NADPH
-
Pseudomonas fluorescens