Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Methimazole | - |
Bos taurus | |
Methimazole | - |
Oryctolagus cuniculus | |
Methimazole | - |
Sus scrofa | |
trimethylamine | - |
Bos taurus | |
trimethylamine | - |
Oryctolagus cuniculus | |
trimethylamine | - |
Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Michaelis-Menten kinetics, overview | Sus scrofa | |
additional information | - |
additional information | Michaelis-Menten kinetics, overview | Bos taurus | |
additional information | - |
additional information | Michaelis-Menten kinetics, overview | Oryctolagus cuniculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Sus scrofa | - |
- |
microsome | - |
Bos taurus | - |
- |
microsome | - |
Oryctolagus cuniculus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzydamine + NADPH + H+ + O2 | Sus scrofa | - |
benzydamine N-oxide + NADP+ + H2O | - |
? | |
benzydamine + NADPH + H+ + O2 | Bos taurus | - |
benzydamine N-oxide + NADP+ + H2O | - |
? | |
benzydamine + NADPH + H+ + O2 | Oryctolagus cuniculus | - |
benzydamine N-oxide + NADP+ + H2O | - |
? | |
additional information | Sus scrofa | benzydamine is a weak base and an indazole derivative with analgesic and antipyretic properties used in human and veterinary medicine, it is metabolized to a wide range of metabolites. One of the main metabolites, benzydamine N-oxide is produced in the liver and brain by flavin-containing monooxygenases | ? | - |
? | |
additional information | Bos taurus | benzydamine is a weak base and an indazole derivative with analgesic and antipyretic properties used in human and veterinary medicine, it is metabolized to a wide range of metabolites. One of the main metabolites, benzydamine N-oxide is produced in the liver and brain by flavin-containing monooxygenases | ? | - |
? | |
additional information | Oryctolagus cuniculus | benzydamine is a weak base and an indazole derivative with analgesic and antipyretic properties used in human and veterinary medicine, it is metabolized to a wide range of metabolites. One of the main metabolites, benzydamine N-oxide is produced in the liver and brain by flavin-containing monooxygenases | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Sus scrofa | - |
brain | - |
Bos taurus | - |
brain | - |
Oryctolagus cuniculus | - |
liver | - |
Sus scrofa | - |
liver | - |
Bos taurus | - |
liver | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzydamine + NADPH + H+ + O2 | - |
Sus scrofa | benzydamine N-oxide + NADP+ + H2O | - |
? | |
benzydamine + NADPH + H+ + O2 | - |
Bos taurus | benzydamine N-oxide + NADP+ + H2O | - |
? | |
benzydamine + NADPH + H+ + O2 | - |
Oryctolagus cuniculus | benzydamine N-oxide + NADP+ + H2O | - |
? | |
additional information | benzydamine is a weak base and an indazole derivative with analgesic and antipyretic properties used in human and veterinary medicine, it is metabolized to a wide range of metabolites. One of the main metabolites, benzydamine N-oxide is produced in the liver and brain by flavin-containing monooxygenases | Sus scrofa | ? | - |
? | |
additional information | benzydamine is a weak base and an indazole derivative with analgesic and antipyretic properties used in human and veterinary medicine, it is metabolized to a wide range of metabolites. One of the main metabolites, benzydamine N-oxide is produced in the liver and brain by flavin-containing monooxygenases | Bos taurus | ? | - |
? | |
additional information | benzydamine is a weak base and an indazole derivative with analgesic and antipyretic properties used in human and veterinary medicine, it is metabolized to a wide range of metabolites. One of the main metabolites, benzydamine N-oxide is produced in the liver and brain by flavin-containing monooxygenases | Oryctolagus cuniculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FMO | - |
Sus scrofa |
FMO | - |
Bos taurus |
FMO | - |
Oryctolagus cuniculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Sus scrofa |
37 | - |
assay at | Bos taurus |
37 | - |
assay at | Oryctolagus cuniculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Sus scrofa |
7.4 | - |
assay at | Bos taurus |
7.4 | - |
assay at | Oryctolagus cuniculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
flavin | - |
Sus scrofa | |
flavin | - |
Bos taurus | |
flavin | - |
Oryctolagus cuniculus | |
NADPH | - |
Sus scrofa | |
NADPH | - |
Bos taurus | |
NADPH | - |
Oryctolagus cuniculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics, overview | Sus scrofa | |
additional information | - |
additional information | inhibition kinetics, overview | Bos taurus | |
additional information | - |
additional information | inhibition kinetics, overview | Oryctolagus cuniculus |