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Literature summary for 1.14.13.8 extracted from

  • Aktas, D.; Can Demirdögen, B.; Adali, O.
    Metabolism of methimazole by bovine liver microsomal flavine monooxygenase: modulation by imipramine and chlorpromazine, comparison with sheep enzyme (2009), Turk. J. Biochem., 34, 44-50.
No PubMed abstract available
Search for more literature for 1.14.13.8

Inhibitors

Inhibitors Comment Organism Structure
chlorpromazine competitively inhibits oxygenation of methimazole by FMO Bos taurus
imipramine competitively inhibits oxygenation of methimazole by FMO Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.11
-
 Methimazole pH 8.0, 37°C Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Bos taurus
-
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00238
-
 liver microsomes, substrate methimazole Bos taurus
0.00373
-
 liver microsomes, substrate imipramine Bos taurus
0.00375
-
 liver microsomes, substrate chlorpromazine Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
chlorpromazine + NADPH + H+ + O2
-
 Bos taurus chlorpromazine oxide + NADP+ + H2O
-
 ?
imipramine + NADPH + H+ + O2
-
 Bos taurus imipramine oxide + NADP+ + H2O
-
 ?
methimazole + NADPH + H+ + O2
-
 Bos taurus methimazole S-oxide + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
FMO
-
 Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
 Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
 Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Bos taurus