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Literature summary for 1.14.13.8 extracted from

  • Vyas, P.M.; Roychowdhury, S.; Koukouritaki, S.B.; Hines, R.N.; Krueger, S.K.; Williams, D.E.; Nauseef, W.M.; Svensson, C.K.
    Enzyme-mediated protein haptenation of dapsone and sulfamethoxazole in human keratinocytes: II. Expression and role of flavin-containing monooxygenases and peroxidases (2006), J. Pharmacol. Exp. Ther., 319, 497-505.
    View publication on PubMed
Search for more literature for 1.14.13.8

Cloned(Commentary)

Cloned (Comment) Organism
independent expression of isozymes FMO1 and FMO3 in Spodoptera frugiperda Sf9 insect cell microsomes via baculovirus transfection system Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-aminobenzoic acid hydrazide + NADPH + O2 Homo sapiens
-
 ?
-
 ?
dapsone + NADPH + O2 Homo sapiens bioactivation by isozyme FMO3, not FMO1, results in covalent adduct formation ?
-
 ?
methimazole + NADPH + O2 Homo sapiens
-
 ?
-
 ?
additional information Homo sapiens arylamine compounds, such as sulfamethoxazole and dapsone, are metabolized in epidermal keratinocytes to arylhydroxylamine metabolites that autooxidize to arylnitroso derivatives, which in turn bind to cellular proteins and can act as antigens/immunogens, methimazole and 4-aminobenzoic acid hydrazide attenuate the protein haptenation, overview ?
-
 ?
sulfamethoxazole + NADPH + O2 Homo sapiens bioactivation by isozyme FMO3, not FMO1, results in covalent adduct formation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q01740
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis
-
 Homo sapiens
-
keratinocyte
-
 Homo sapiens
-
NHEK cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-aminobenzoic acid hydrazide + NADPH + O2
-
 Homo sapiens ?
-
 ?
dapsone + NADPH + O2 bioactivation by isozyme FMO3, not FMO1, results in covalent adduct formation Homo sapiens ?
-
 ?
dapsone + NADPH + O2 isozyme FMO3, not FMO1 Homo sapiens ?
-
 ?
methimazole + NADPH + O2
-
 Homo sapiens ?
-
 ?
additional information arylamine compounds, such as sulfamethoxazole and dapsone, are metabolized in epidermal keratinocytes to arylhydroxylamine metabolites that autooxidize to arylnitroso derivatives, which in turn bind to cellular proteins and can act as antigens/immunogens, methimazole and 4-aminobenzoic acid hydrazide attenuate the protein haptenation, overview Homo sapiens ?
-
 ?
sulfamethoxazole + NADPH + O2 bioactivation by isozyme FMO3, not FMO1, results in covalent adduct formation Homo sapiens ?
-
 ?
sulfamethoxazole + NADPH + O2 isozyme FMO3, not FMO1 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
FMO
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Homo sapiens
NADPH
-
 Homo sapiens