Literature summary for 1.14.13.8 extracted from

Cashman, J.R.; Xiong, Y.; Lin, J.; Verhagen, H.; van Poppel, G.; van Bladeren, P.J.; Larsen-Su, S.; Williams, D.
In vitro and in vivo inhibition of human flavin-containing monooxygenase form 3 (FMO3) in the presence of dietary indoles (1999), Biochem. Pharmacol., 58, 1047-1055.

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Inhibitors

Inhibitors	Comment	Organism	Structure
indole-3-carbinol	and its acid condensation products, strong	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	diet of Brussels sprouts	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
urine	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
10-([N,N-dimethylaminopentyl]-2-trifluoromethyl)phenothiazine + NADPH + O2	-	Homo sapiens	?	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.008	0.013	indole-3-carbinol	-	Homo sapiens

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Release 2023.1 (January 2023)