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Literature summary for 1.14.13.7 extracted from

  • Zhan, Y.; Yu, H.; Yan, Y.; Ping, S.; Lu, W.; Zhang, W.; Chen, M.; Lin, M.
    Benzoate catabolite repression of the phenol degradation in Acinetobacter calcoaceticus PHEA-2 (2009), Curr. Microbiol., 59, 368-373.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
additional information benzoate causes transcriptional repression of phenol utilization by transcriptional inhibition of the mph operon. MphR encoding the transcriptional activator and mphN encoding the largest subunit of multi-component phenol hydroxylase in the benA mutant are significantly downregulated (about 7- and 70fold) on the basis of mRNA levels when benzoate is added to the medium Acinetobacter calcoaceticus

Organism

Organism UniProt Comment Textmining
Acinetobacter calcoaceticus
-
 strains PHEA-2 or PHEA-12
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phenol + NAD(P)H + H+ + O2
-
 Acinetobacter calcoaceticus catechol + NAD(P)+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
MphN
-
 Acinetobacter calcoaceticus
multi-component phenol hydroxylase
-
 Acinetobacter calcoaceticus

Expression

Organism Comment Expression
Acinetobacter calcoaceticus expression of mphN encoding the largest subunit of multi-component phenol hydroxylase is reduced 70fold in the presence of both phenol and benzoate. Repression of mphN transcription is specifically released in the presence of benzoate down