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Literature summary for 1.14.13.39 extracted from

  • Dooley, A.; Low, S.Y.; Holmes, A.; Kidane, A.G.; Abraham, D.J.; Black, C.M.; Bruckdorfer, K.R.
    Nitric oxide synthase expression and activity in the tight-skin mouse model of fibrosis (2008), Rheumatology, 47, 272-280.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information there is decreased eNOS activity in tight-skin 1-mouse skin tissue Mus musculus
N(G)-nitroarginine methyl ester
-
Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P70313 tight-skin 1 mouse strain
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Mus musculus
-
endothelial cell
-
Mus musculus
-
hair follicle
-
Mus musculus
-
lung
-
Mus musculus
-
skin n the skin, eNOS is present in the epidermal layer, hair follicles and also in the endothelial cells lining the blood vessels Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-arginine + 3 NADPH + 3 H+ + 4 O2
-
Mus musculus 2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
-
?

Synonyms

Synonyms Comment Organism
endothelial nitric oxide synthase
-
Mus musculus
eNOS
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
5,6,7,8-tetrahydro-L-biopterin
-
Mus musculus
Calmodulin
-
Mus musculus
NADPH
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus expression of both the eNOS protein and gene is significantly reduced in tight-skin 1-mouse skin tissue up