Literature summary for 1.14.13.39 extracted from

de Visser, S.P.; Tan, L.S.
Is the bound substrate in nitric oxide synthase protonated or neutral and what is the active oxidant that performs substrate hydroxylation? (2008), J. Am. Chem. Soc., 130, 12961-12974.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2 L-arginine + 2 NADPH + 2 H+ + 2 O2	first half reaction	Homo sapiens	2 Nomega-hydroxy-L-arginine + 2 NADP+ + 2 H2O	-	ir
Nomega-hydroxy-L-arginine + NADPH + H+ + O2	second half reaction	Homo sapiens	L-citrulline + NADP+ + NO + H2O	-	?

Synonyms

Synonyms	Comment	Organism
cytokine inducible NOS	-	Homo sapiens
endothelial NOS	-	Homo sapiens
eNOS	-	Homo sapiens
iNOS	-	Homo sapiens
neuronal NOS	-	Homo sapiens
nNOS	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
5,6,7,8-tetrahydro-L-biopterin	-	Homo sapiens
Calmodulin	-	Homo sapiens
NADPH	-	Homo sapiens

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Release 2023.1 (January 2023)