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Literature summary for 1.14.13.39 extracted from

  • Moreau, M.; Takahashi, H.; Sari, M.A.; Boucher, J.L.; Sagami, I.; Shimizu, T.; Mansuy, D.
    Importance of valine 567 in substrate recognition and oxidation by neuronal nitric oxide synthase (2004), J. Inorg. Biochem., 98, 1200-1209.
    View publication on PubMed
Search for more literature for 1.14.13.39

Protein Variants

Protein Variants Comment Organism
V567E little stability, no enzymic activity Rattus norvegicus
V567F enzymic activity only with N-hydroxy-L-arginine Rattus norvegicus
V567L little production of NO, lower affinity for L-arginine and N-hydroxy-L-arginine than wild-type Rattus norvegicus
V567R little stability, no enzymic activity Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P29476 neuronal enzyme
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-butyl-2-hydroxyguanidine + NADPH + O2
-
 Rattus norvegicus ? + NO + NADP+
-
 ?
2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
 Rattus norvegicus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
 ?
2-hydroxy-1-(4-hydroxyphenyl)guanidine + NADPH + O2
-
 Rattus norvegicus ? + NO + NADP+
-
 ?
2-hydroxy-1-isopropylguanidine + NADPH + O2
-
 Rattus norvegicus ? + NO + NADP+
-
 ?
N-hydroxy-L-arginine + NADPH + O2
-
 Rattus norvegicus ? + NO + NADP+
-
 ?