Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | neopterin derivatives are completely inactive and do not bind to the enzyme | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ngamma-monomethyl-L-arginine | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | absolutely dependent on | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | NO represents the endogenous activator of soluble guanylyl cyclase | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cervical carcinoma cell | cell line ME-180, constitutive expression | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 L-arginine + 3 NADPH + 4 O2 + 3 H+ | - |
Homo sapiens | 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O | the product is a guanylyl-cyclase-relaxing factor, that is identical with nitric oxide or a NO-releasing compound | ? | |
additional information | NO represents the endogenous activator of soluble guanylyl cyclase | Homo sapiens | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
5,6,7,8-tetrahydro-L-biopterin | required | Homo sapiens | |
Calmodulin | - |
Homo sapiens | |
FAD | required | Homo sapiens | |
FMN | required | Homo sapiens | |
NADPH | dependent on | Homo sapiens |