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Literature summary for 1.14.13.39 extracted from

  • Werner-Felmayer, G.; Werner, E.R.; Fuchs, D.; Hausen, A.; Mayer, B.; Reibnegger, G.; Weiss, G.; Wachter, H.
    Calcium/calmodulin-dependent nitric oxide synthase activity in the human cervix carcinoma cell line ME-180 (1993), Biochem. J., 289, 357-361.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
additional information neopterin derivatives are completely inactive and do not bind to the enzyme Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Ngamma-monomethyl-L-arginine
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ absolutely dependent on Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens NO represents the endogenous activator of soluble guanylyl cyclase ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cervical carcinoma cell cell line ME-180, constitutive expression Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
Homo sapiens 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O the product is a guanylyl-cyclase-relaxing factor, that is identical with nitric oxide or a NO-releasing compound ?
additional information NO represents the endogenous activator of soluble guanylyl cyclase Homo sapiens ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
5,6,7,8-tetrahydro-L-biopterin required Homo sapiens
Calmodulin
-
Homo sapiens
FAD required Homo sapiens
FMN required Homo sapiens
NADPH dependent on Homo sapiens