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Literature summary for 1.14.13.39 extracted from

  • Stuehr, D.J.; Ikeda-Saito, M.
    Spectral characterization of brain and macrophage nitric oxide synthases. Cytochrome P-450-like hemeproteins that contain a flavin semiquinone radical (1992), J. Biol. Chem., 267, 20547-20550.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
rat brain enzyme expressed in human 293 kidney cells transfected with a vector encoding rat brain enzyme Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
CO
-
Mus musculus
CO
-
Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Iron 2 mol iron-protoporphyrin IX per mol enzyme dimer, the heme-iron is ferric, EPR-and light absorbance spectroscopy Mus musculus
Iron 2 mol iron-protoporphyrin IX per mol enzyme dimer, the heme-iron is ferric, EPR-and light absorbance spectroscopy Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 L-arginine + 3 NADPH + 4 O2 + 3 H+ Mus musculus acts as signal molecule for neurotransmission, vasorelaxation, and cytotoxity 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?
2 L-arginine + 3 NADPH + 4 O2 + 3 H+ Rattus norvegicus acts as signal molecule for neurotransmission, vasorelaxation, and cytotoxity 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
2',5'-ADP-agarose affinity chromatography Rattus norvegicus

Reaction

Reaction Comment Organism Reaction ID
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O cytochrome P-450 enzyme Mus musculus
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O cytochrome P-450 enzyme Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
brain
-
Rattus norvegicus
-
macrophage cytokine-activated Mus musculus
-
macrophage cytokine-activated Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
Mus musculus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O probably via Nomega-hydroxy-L-arginine ?
2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
Rattus norvegicus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O probably via Nomega-hydroxy-L-arginine ?
2 L-arginine + 3 NADPH + 4 O2 + 3 H+ acts as signal molecule for neurotransmission, vasorelaxation, and cytotoxity Mus musculus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?
2 L-arginine + 3 NADPH + 4 O2 + 3 H+ acts as signal molecule for neurotransmission, vasorelaxation, and cytotoxity Rattus norvegicus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus
37
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
FAD FAD containing flavoprotein Mus musculus
FAD FAD containing flavoprotein Rattus norvegicus
FMN FMN containing flavoprotein Mus musculus
FMN FMN containing flavoprotein Rattus norvegicus
NADPH
-
Mus musculus
NADPH
-
Rattus norvegicus