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Literature summary for 1.14.13.34 extracted from
- omega-Oxidation of cysteine-containing leukotrienes by rat-liver microsomes (1987), Eur. J. Biochem., 170, 77-85.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + O2 | Rattus norvegicus | metabolism of leukotriene E4 and N-acetyl-leukotriene E4 in rat liver microsomes | 20-hydroxy-leukotriene E4 + NADP+ + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male Sprague Dawley rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | the specific activity is about 12times lower than for liver | Rattus norvegicus | - |
| liver | highest activity | Rattus norvegicus | - |
| lung | the specific activity is about 12times lower than for liver | Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + O2 | leukotriene E4 | Rattus norvegicus | 20-hydroxy-leukotriene E4 + NADP+ + H2O | omega-hydroxy-leukotriene E4 | ? | |
| (7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + O2 | metabolism of leukotriene E4 and N-acetyl-leukotriene E4 in rat liver microsomes | Rattus norvegicus | 20-hydroxy-leukotriene E4 + NADP+ + H2O | - |
? | |
| N-acetyl-leukotriene E4 + NADPH + O2 | at a rate six times lower than leukotriene E4 | Rattus norvegicus | N-acetyl-omega-hydroxy-leukotriene E4 + NADP+ + H2O | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Rattus norvegicus | |
| O2 | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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