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Literature summary for 1.14.13.29 extracted from
- The effect of aspartame on rat brain xenobiotic-metabolizing enzymes (2006), Hum. Exp. Toxicol., 25, 453-459.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | chronic abuse aspartame leads to 1.5fold increased enzyme activity in cerebrum and 25-fold in cerebellum, pattern of induction of CYP immunoreactive proteins, specific induction in the brain, not in hepatocytes, overview | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitrophenol + NAD(P)H + O2 | Rattus norvegicus | - |
4-nitrocatechol + NAD(P)+ + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| cerebellum | - |
Rattus norvegicus | - |
| cerebrum | - |
Rattus norvegicus | - |
| hepatocyte | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitrophenol + NAD(P)H + O2 | - |
Rattus norvegicus | 4-nitrocatechol + NAD(P)+ + H2O | - |
? | |
| 4-nitrophenol + NADPH + O2 | - |
Rattus norvegicus | 4-nitrocatechol + NADP+ + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 4-nitrophenol hydroxylase | - |
Rattus norvegicus |
| 4-NPH | - |
Rattus norvegicus |
| CYP2E1 | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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