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Literature summary for 1.14.13.25 extracted from

  • Zhang, Y.; Xin, J.; Chen, L.; Xia, C.
    The methane monooxygenase intrinsic activity of kinds of methanotrophs (2009), Appl. Biochem. Biotechnol., 157, 431-441.
    View publication on PubMed

Application

Application Comment Organism
biotechnology high particulate methane monooxygenase activity may contribute to the synthesis of poly-beta-hydroxybutyrate in the cell, which may be used to improve the yield of poly-beta-hydroxybutyrate in methanotrophs Methylococcus capsulatus
biotechnology high particulate methane monooxygenase activity may contribute to the synthesis of poly-beta-hydroxybutyrate in the cell, which may be used to improve the yield of poly-beta-hydroxybutyrate in methanotrophs Methylomonas sp. GYJ3
biotechnology high particulate methane monooxygenase activity may contribute to the synthesis of poly-beta-hydroxybutyrate in the cell, which may be used to improve the yield of poly-beta-hydroxybutyrate in methanotrophs. Poly-beta-hydroxybutyrate content of strain OB3b can reach the highest level in the shortest time as compared to other methanotrophs. Nutrients deficiency condition is beneficial for strain IMV3011 to synthesize PHB whereas it is not beneficial for other strains Methylosinus trichosporium

Inhibitors

Inhibitors Comment Organism Structure
additional information when cultivated in nutrients deficiency culture, activity of sMMO does not decrease Methylococcus capsulatus
additional information when cultivated in nutrients deficiency culture, activity of sMMO decreases Methylomonas sp. GYJ3
additional information when cultivated in nutrients deficiency culture, activity of sMMO in strain OB3b decreases, whereas activity of sMMO in strain IMV3011 does not decrease Methylosinus trichosporium
poly-beta-hydroxybutyrate MMO activity dramatically decreases when cellular poly-beta-hydroxybutyrate accumulates in the second stage. The more poly-beta-hydroxybutyrate are accumulated, the slower MMO activity decreases. Cellular poly-beta-hydroxybutyrate content has some influence on the maintenance of the MMO activity Methylococcus capsulatus
poly-beta-hydroxybutyrate MMO activity dramatically decreases when cellular poly-beta-hydroxybutyrate accumulates in the second stage. The more poly-beta-hydroxybutyrate are accumulated, the slower MMO activity decreases. Cellular poly-beta-hydroxybutyrate content has some influence on the maintenance of the MMO activity Methylomonas sp. GYJ3
poly-beta-hydroxybutyrate MMO activity dramatically decreases when cellular poly-beta-hydroxybutyrate accumulates in the second stage. The more poly-beta-hydroxybutyrate are accumulated, the slower MMO activity decreases. Cellular poly-beta-hydroxybutyrate content has some influence on the maintenance of the MMO activity Methylosinus trichosporium

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Methylococcus capsulatus 5737
-
cytoplasm
-
Methylosinus trichosporium 5737
-
cytoplasm
-
Methylomonas sp. 5737
-
cytoplasm sMMO Methylococcus capsulatus 5737
-
cytoplasm sMMO Methylosinus trichosporium 5737
-
cytoplasm sMMO Methylomonas sp. GYJ3 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ cells adapted to the respective medium, either lacking Cu (sMMO production) or containing 0.01 mM Cu (pMMO production) Methylococcus capsulatus
Cu2+ cells adapted to the respective medium, either lacking Cu (sMMO production) or containing 0.01 mM Cu (pMMO production) Methylosinus trichosporium
Cu2+ cells adapted to the respective medium, either lacking Cu (sMMO production) or containing 0.01 mM Cu (pMMO production) Methylomonas sp. GYJ3
additional information sMMO activity and expression does not require Cu2+ Methylococcus capsulatus
additional information sMMO activity and expression does not require Cu2+ Methylosinus trichosporium
additional information sMMO activity and expression does not require Cu2+ Methylomonas sp.

Organism

Organism UniProt Comment Textmining
Methylococcus capsulatus
-
-
-
Methylococcus capsulatus
-
HD6T
-
Methylococcus capsulatus HD6T
-
-
-
Methylococcus capsulatus HD6T
-
HD6T
-
Methylomonas sp.
-
-
-
Methylomonas sp. GYJ3
-
-
-
Methylosinus trichosporium
-
-
-
Methylosinus trichosporium
-
strains OB3b and IMV3011
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methane + NADH + H+ + O2
-
Methylococcus capsulatus methanol + NAD+ + H2O
-
?
methane + NADH + H+ + O2
-
Methylosinus trichosporium methanol + NAD+ + H2O
-
?
methane + NADH + H+ + O2
-
Methylomonas sp. methanol + NAD+ + H2O
-
?
methane + NADH + H+ + O2
-
Methylococcus capsulatus HD6T methanol + NAD+ + H2O
-
?
additional information pMMO has broader substrate specificity but lower activity with smaller hydrocarbons like methane, ethane, and propene compared to pMMO Methylococcus capsulatus ?
-
?
additional information pMMO has broader substrate specificity but lower activity with smaller hydrocarbons like methane, ethane, and propene compared to pMMO Methylosinus trichosporium ?
-
?
additional information pMMO has broader substrate specificity but lower activity with smaller hydrocarbons like methane, ethane, and propene compared to pMMO Methylomonas sp. ?
-
?
additional information pMMO has broader substrate specificity but lower activity with smaller hydrocarbons like methane, ethane, and propene compared to pMMO Methylococcus capsulatus HD6T ?
-
?
naphthalene + NAD(P)H + O2 oxidized by sMMO Methylococcus capsulatus alpha-naphthol + beta-naphthol + NAD(P)+ + H2O
-
?
naphthalene + NAD(P)H + O2 oxidized by sMMO Methylosinus trichosporium alpha-naphthol + beta-naphthol + NAD(P)+ + H2O
-
?
naphthalene + NAD(P)H + O2 oxidized by sMMO Methylomonas sp. GYJ3 alpha-naphthol + beta-naphthol + NAD(P)+ + H2O
-
?
naphthalene + NAD(P)H + O2 oxidized by sMMO Methylococcus capsulatus HD6T alpha-naphthol + beta-naphthol + NAD(P)+ + H2O
-
?
naphthalene + NADH + H+
-
Methylococcus capsulatus alpha-naphthol + beta-naphthol + NAD+ + H2O
-
?
naphthalene + NADH + H+
-
Methylosinus trichosporium alpha-naphthol + beta-naphthol + NAD+ + H2O
-
?
naphthalene + NADH + H+
-
Methylomonas sp. alpha-naphthol + beta-naphthol + NAD+ + H2O
-
?
naphthalene + NADH + H+
-
Methylococcus capsulatus HD6T alpha-naphthol + beta-naphthol + NAD+ + H2O
-
?
propene + NAD(P)H + O2
-
Methylococcus capsulatus 1,2-epoxypropane + NAD(P)+ + H2O
-
?
propene + NAD(P)H + O2
-
Methylosinus trichosporium 1,2-epoxypropane + NAD(P)+ + H2O
-
?
propene + NAD(P)H + O2
-
Methylomonas sp. GYJ3 1,2-epoxypropane + NAD(P)+ + H2O
-
?
propene + NAD(P)H + O2
-
Methylococcus capsulatus HD6T 1,2-epoxypropane + NAD(P)+ + H2O
-
?
propene + NADH + H+ + O2
-
Methylococcus capsulatus epoxypropane + NAD+ + H2O
-
?
propene + NADH + H+ + O2
-
Methylosinus trichosporium epoxypropane + NAD+ + H2O
-
?
propene + NADH + H+ + O2
-
Methylomonas sp. epoxypropane + NAD+ + H2O
-
?

Synonyms

Synonyms Comment Organism
MMO
-
Methylococcus capsulatus
MMO
-
Methylosinus trichosporium
MMO
-
Methylomonas sp. GYJ3
particulate methane monooxygenase
-
Methylococcus capsulatus
particulate methane monooxygenase
-
Methylosinus trichosporium
particulate methane monooxygenase
-
Methylomonas sp. GYJ3
pMMO
-
Methylococcus capsulatus
pMMO
-
Methylosinus trichosporium
pMMO
-
Methylomonas sp. GYJ3
sMMO
-
Methylococcus capsulatus
sMMO
-
Methylosinus trichosporium
sMMO
-
Methylomonas sp.
sMMO
-
Methylomonas sp. GYJ3
soluble methane monooxygenase
-
Methylococcus capsulatus
soluble methane monooxygenase
-
Methylosinus trichosporium
soluble methane monooxygenase
-
Methylomonas sp.

Cofactor

Cofactor Comment Organism Structure
NADH
-
Methylococcus capsulatus
NADH
-
Methylosinus trichosporium
NADH
-
Methylomonas sp. GYJ3
NADPH
-
Methylococcus capsulatus
NADPH
-
Methylosinus trichosporium
NADPH
-
Methylomonas sp. GYJ3

Expression

Organism Comment Expression
Methylococcus capsulatus sMMO is expressed at low copper/biomass ratios up
Methylosinus trichosporium sMMO is expressed at low copper/biomass ratios up
Methylomonas sp. sMMO is expressed at low copper/biomass ratios up