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Literature summary for 1.14.13.22 extracted from

  • Zambianchi, F.; Raimondi, S.; Pasta, P.; Carrea, G.; Gaggero, N.; Woodley, J.M.
    Comparison of cyclohexanone monooxygenase as an isolated enzyme and whole cell biocatalyst for the enantioselective oxidation of 1,3-dithiane (2004), J. Mol. Catal. B, 31, 165-171.
No PubMed abstract available
Search for more literature for 1.14.13.22

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli TOP10 Acinetobacter calcoaceticus

Inhibitors

Inhibitors Comment Organism Structure
1,3-dithiane substrate inhibition Acinetobacter calcoaceticus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.045
-
 1,3-dithiane pH 8.6, 25°C Acinetobacter calcoaceticus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cyclohexanone + NADPH + O2 Acinetobacter calcoaceticus
-
 hexano-6-lactone + NADP+ + H2O
-
 ?
cyclohexanone + NADPH + O2 Acinetobacter calcoaceticus NCIMB 9871
-
 hexano-6-lactone + NADP+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Acinetobacter calcoaceticus
-
 NCIMB 9871
-
Acinetobacter calcoaceticus NCIMB 9871
-
 NCIMB 9871
-

Purification (Commentary)

Purification (Comment) Organism
partial purification of recombinant enzyme Acinetobacter calcoaceticus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,3-dithiane + NADPH + O2
-
 Acinetobacter calcoaceticus (R)-1,3-dithiane-1-oxide + NADP+ + H2O
-
 ?
1,3-dithiane + NADPH + O2
-
 Acinetobacter calcoaceticus NCIMB 9871 (R)-1,3-dithiane-1-oxide + NADP+ + H2O
-
 ?
cyclohexanone + NADPH + O2
-
 Acinetobacter calcoaceticus hexano-6-lactone + NADP+ + H2O
-
 ?
cyclohexanone + NADPH + O2
-
 Acinetobacter calcoaceticus NCIMB 9871 hexano-6-lactone + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
cyclohexanone:NADPH:oxygen oxidoreductase (lactone-forming)
-
 Acinetobacter calcoaceticus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Acinetobacter calcoaceticus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
15
-
 1,3-dithiane pH 8.6, 25°C Acinetobacter calcoaceticus