Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.13.2 extracted from

  • Abe, I.; Kashiwagi, K.; Noguchi, H.
    Antioxidative galloyl esters as enzyme inhibitors of p-hydroxybenzoate hydroxylase (2000), FEBS Lett., 483, 131-134.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Pseudomonas aeruginosa

Inhibitors

Inhibitors Comment Organism Structure
(-)-epigallocatechin-3-O-gallate non-competitive, binds to the enzyme in the proximity of the FAD binding site via formation of three hydrogen bonds Pseudomonas aeruginosa
n-dodecyl gallate non-competitive Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
-
-
Pseudomonas fluorescens P00438
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-hydroxybenzoate + NADPH + O2
-
Pseudomonas aeruginosa protocatechuate + NADP+ + H2O
-
?
4-hydroxybenzoate + NADPH + O2
-
Pseudomonas fluorescens protocatechuate + NADP+ + H2O
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.014
-
(-)-epigallocatechin-3-O-gallate
-
Pseudomonas aeruginosa
0.0181
-
n-dodecyl gallate
-
Pseudomonas aeruginosa