Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dTDP-beta-L-evernosamine + 2 NADPH + 2 H+ + 2 O2 | Micromonospora carbonacea | overall reaction, dTDP-beta-L-evernosamine i.e. dTDP-3-amino-2,3,6-trideoxy-3-C-methyl-4-O-methyl-beta-L-arabino-hexopyranose. The nitroso group is probably spontaneously oxidized to a nitro group giving dTDP-beta-L-evernitrose, which is involved in the biosynthesis of the antibiotic everninomycin | dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 NADP+ + 3 H2O | - |
? | |
dTDP-beta-L-evernosamine + 2 NADPH + 2 H+ + 2 O2 | Micromonospora carbonacea var. africana | overall reaction, dTDP-beta-L-evernosamine i.e. dTDP-3-amino-2,3,6-trideoxy-3-C-methyl-4-O-methyl-beta-L-arabino-hexopyranose. The nitroso group is probably spontaneously oxidized to a nitro group giving dTDP-beta-L-evernitrose, which is involved in the biosynthesis of the antibiotic everninomycin | dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 NADP+ + 3 H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Micromonospora carbonacea | - |
- |
- |
Micromonospora carbonacea var. africana | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
dTDP-beta-L-evernosamine + 2 NADPH + 2 H+ + 2 O2 = dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 NADP+ + 3 H2O | (overall reaction) | Micromonospora carbonacea | |
dTDP-beta-L-evernosamine + NADPH + H+ + O2 = dTDP-N-hydroxy-beta-L-evernosamine + NADP+ + H2O | (1a) | Micromonospora carbonacea | |
dTDP-N-hydroxy-beta-L-evernosamine + NADPH + H+ + O2 = dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + NADP+ + 2 H2O | (1b) | Micromonospora carbonacea |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dTDP-beta-L-evernosamine + 2 NADPH + 2 H+ + 2 O2 | overall reaction, dTDP-beta-L-evernosamine i.e. dTDP-3-amino-2,3,6-trideoxy-3-C-methyl-4-O-methyl-beta-L-arabino-hexopyranose. The nitroso group is probably spontaneously oxidized to a nitro group giving dTDP-beta-L-evernitrose, which is involved in the biosynthesis of the antibiotic everninomycin | Micromonospora carbonacea | dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 NADP+ + 3 H2O | - |
? | |
dTDP-beta-L-evernosamine + 2 NADPH + 2 H+ + 2 O2 | overall reaction, dTDP-beta-L-evernosamine i.e. dTDP-3-amino-2,3,6-trideoxy-3-C-methyl-4-O-methyl-beta-L-arabino-hexopyranose. The nitroso group is probably spontaneously oxidized to a nitro group giving dTDP-beta-L-evernitrose, which is involved in the biosynthesis of the antibiotic everninomycin | Micromonospora carbonacea var. africana | dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 NADP+ + 3 H2O | - |
? | |
dTDP-beta-L-evernosamine + NADPH + H+ + O2 | dTDP-beta-L-evernosamine i.e. dTDP-3-amino-2,3,6-trideoxy-3-C-methyl-4-O-methyl-beta-L-arabino-hexopyranose | Micromonospora carbonacea | dTDP-N-hydroxy-beta-L-evernosamine + NADP+ + H2O | - |
? | |
dTDP-beta-L-evernosamine + NADPH + H+ + O2 | dTDP-beta-L-evernosamine i.e. dTDP-3-amino-2,3,6-trideoxy-3-C-methyl-4-O-methyl-beta-L-arabino-hexopyranose | Micromonospora carbonacea var. africana | dTDP-N-hydroxy-beta-L-evernosamine + NADP+ + H2O | - |
? | |
dTDP-N-hydroxy-beta-L-evernosamine + NADPH + H+ + O2 | dTDP-beta-L-evernosamine i.e. dTDP-3-amino-2,3,6-trideoxy-3-C-methyl-4-O-methyl-beta-L-arabino-hexopyranose | Micromonospora carbonacea | dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + NADP+ + 2 H2O | - |
? | |
dTDP-N-hydroxy-beta-L-evernosamine + NADPH + H+ + O2 | dTDP-beta-L-evernosamine i.e. dTDP-3-amino-2,3,6-trideoxy-3-C-methyl-4-O-methyl-beta-L-arabino-hexopyranose | Micromonospora carbonacea var. africana | dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + NADP+ + 2 H2O | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | required | Micromonospora carbonacea | |
NADPH | - |
Micromonospora carbonacea |