Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
aklavinone + NADPH + H+ + O2 | Streptomyces purpurascens | the enzyme is involved in the biosynthesis of the anthracycline antibiotic daunorubicin/doxorubicin pathway. During the biosynthesis of L-rhodomycins, RdmE first modifies aklavinone at C-11, and epsilon-rhodomycinone or aklavinone is subsequently glycosylated | epsilon-rhodomycinone + NADP+ + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces purpurascens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Streptomyces purpurascens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-deoxy-beta-L-rhodomycinone + NADPH + H+ + O2 | 11-deoxy-L-rhodomycinone is a better substrate than aklavinone | Streptomyces purpurascens | beta-rhodomycinone + NADP+ + H2O | - |
? | |
aklavinone + NADPH + H+ + O2 | the enzyme is involved in the biosynthesis of the anthracycline antibiotic daunorubicin/doxorubicin pathway. During the biosynthesis of L-rhodomycins, RdmE first modifies aklavinone at C-11, and epsilon-rhodomycinone or aklavinone is subsequently glycosylated | Streptomyces purpurascens | epsilon-rhodomycinone + NADP+ + H2O | - |
? | |
aklavinone + NADPH + H+ + O2 | about 60% compared to the activity with 11-deoxy-L-rhodomycinone | Streptomyces purpurascens | epsilon-rhodomycinone + NADP+ + H2O | - |
? | |
additional information | no activity with decarbomethoxyaklavinone or 15-demethoxyaklavinone | Streptomyces purpurascens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RdmE | - |
Streptomyces purpurascens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is involved in the biosynthesis of the anthracycline antibiotic daunorubicin/doxorubicin pathway | Streptomyces purpurascens |