Cloned (Comment) | Organism |
---|---|
overexpression of the gene in Streptomyces lividans | Streptomyces purpurascens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,3-Butanedione | - |
Streptomyces purpurascens | |
Phenylglyoxal | NADPH protects against inactivation of aklavinone-11-hydroxylase by phenylglyoxal | Streptomyces purpurascens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.01 | - |
aklavinone | pH and temperature not specified in the publication | Streptomyces purpurascens | |
2 | - |
NADPH | pH and temperature not specified in the publication | Streptomyces purpurascens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
60000 | - |
1 * 60000 | Streptomyces purpurascens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
aklavinone + NADPH + H+ + O2 | Streptomyces purpurascens | - |
epsilon-rhodomycinone + NADP+ + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces purpurascens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
aklavinone + NADH + H+ + O2 | the enzyme participates in the biosynthesis of daunorubicin, doxorubicin and rhodomycins | Streptomyces purpurascens | epsilon-rhodomycinone + NAD+ + H2O | - |
? | |
aklavinone + NADPH + H+ + O2 | - |
Streptomyces purpurascens | epsilon-rhodomycinone + NADP+ + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 60000 | Streptomyces purpurascens |
Synonyms | Comment | Organism |
---|---|---|
RdmE | - |
Streptomyces purpurascens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | the enzyme is a FAD monooxygenase | Streptomyces purpurascens | |
NADH | aklavinone-11-hydroxylase can use both NADH and NADPH as coenzyme but it is slowly inactivated in the presence of NADH | Streptomyces purpurascens | |
NADPH | aklavinone-11-hydroxylase can use both NADH and NADPH as coenzyme but it is slowly inactivated in the presence of NADH | Streptomyces purpurascens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme participates in the biosynthesis of daunorubicin, doxorubicin and rhodomycins | Streptomyces purpurascens |