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Literature summary for 1.14.13.16 extracted from

  • Mihovilovic, M.D.; Bianchi, D.A.; Rudroff, F.
    Accessing tetrahydrofuran-based natural products by microbial Baeyer-Villiger biooxidation (2006), Chem. Commun. (Camb. ), 1, 3214-3216.
    View publication on PubMed
Search for more literature for 1.14.13.16

Application

Application Comment Organism
synthesis the enzyme can be used for accessing tetrahydrofuran-based natural products by stereoselective Baeyer-Villiger biooxidation, in particular for the formation of chiral lactones, natural compound synthesis, completion of the formal total synthesis of (+)-showdomycin and establishing of the absolute configuration of biooxidation product as (1S,6S)-3,9-dioxabicyclo[4.2.1]non-7-en-4-one, overview Comamonas sp.

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in Escherichia coli Comamonas sp.

Protein Variants

Protein Variants Comment Organism
additional information completion of the formal total synthesis of (+)-showdomycin and establishing of the absolute configuration of biooxidation product as (1S,6S)-3,9-dioxabicyclo[4.2.1]non-7-en-4-one, overview Comamonas sp.

Organism

Organism UniProt Comment Textmining
Comamonas sp.
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(1R,5S)-8-oxabicyclo[3.2.1]oct-6-en-3-one + NADPH + O2
-
 Comamonas sp. (1S,6S)-3,9-dioxabicyclo[4.2.1]non-7-en-4-one + NADP+ + H2O stereospecific (1S,6S)-product formation ?

Synonyms

Synonyms Comment Organism
CPMO
-
 Comamonas sp.
More the enzyme belongs to the flavin-containing Baeyer–Villiger monooxygenases, BVMOs Comamonas sp.

Cofactor

Cofactor Comment Organism Structure
FAD enzyme-bound Comamonas sp.
NADPH
-
 Comamonas sp.