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Literature summary for 1.14.13.148 extracted from

  • Catucci, G.; Gilardi, G.; Jeuken, L.; Sadeghi, S.
    In vitro drug metabolism by C-terminally truncated human flavin-containing monooxygenase 3 (2012), Biochem. Pharmacol., 83, 551-558.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
wild type and truncated enzymes are expressed in Escherichia coli JM109 cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.022
-
sulindac sulfide truncated recombinant enzyme, in 50 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
0.025
-
sulindac sulfide wild type enzyme, in 50 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
0.033
-
Methimazole wild type enzyme, in 50 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
0.035
-
Methimazole truncated recombinant enzyme, in 50 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
0.045
-
Benzydamine truncated recombinant enzyme, in 50 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
0.056
-
Benzydamine wild type enzyme, in 50 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
x * 60000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N,N,N-trimethylamine + NADPH + H+ + O2 Homo sapiens
-
N,N,N-trimethylamine N-oxide + NADP+ + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
DEAE ion exchange column chromatography and Ni affinity column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzydamine + NADPH + H+ + O2
-
Homo sapiens benzydamine N-oxide + NADP+ + H2O
-
?
danusertib + NADPH + H+ + O2
-
Homo sapiens danusertib N-oxide + NADP+ + H2O
-
?
methimazole + NADPH + H+ + O2
-
Homo sapiens methimazole N-oxide + NADP+ + H2O
-
?
N,N,N-trimethylamine + NADPH + H+ + O2
-
Homo sapiens N,N,N-trimethylamine N-oxide + NADP+ + H2O
-
?
sulindac sulfide + NADPH + H+ + O2
-
Homo sapiens sulindac + NADP+ + H2O
-
?
tozasertib + NADPH + H+ + O2
-
Homo sapiens tozasertib N-oxide + NADP+ + H2O
-
?

Subunits

Subunits Comment Organism
? x * 60000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
flavin-containing monooxygenase 3
-
Homo sapiens
FMO3
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens
NADPH required for activity Homo sapiens