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Literature summary for 1.14.12.12 extracted from

  • Jeffrey, A.M.; Yeh, H.J.C.; Jerina, D.M.; Patel, T.R.; Davey, J.F.; Gibson, D.T.
    Initial reactions in the oxidation of naphthalene by Pseudomonas putida (1975), Biochemistry, 14, 575-584.
    View publication on PubMed
Search for more literature for 1.14.12.12

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
 three component enzyme system consisting of: component A, i.e. ferredoxinNAP reductase, component B, i.e. terminal oxygenase ISPNAP, and component C, i.e. ferredoxinNAP Pseudomonas putida

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
naphthalene + NADH + O2 Pseudomonas putida initial oxidative reaction in bacterial naphthalene catabolism (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+
-
 ?
naphthalene + NADH + O2 Pseudomonas putida 119 initial oxidative reaction in bacterial naphthalene catabolism (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+
-
 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas putida
-
 unable to grow on naphthalene
-
Pseudomonas putida
-
 wild-type grown on naphthalene
-
Pseudomonas putida 119
-
 unable to grow on naphthalene
-

Reaction

Reaction Comment Organism Reaction ID
naphthalene + NADH + H+ + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+ proposed mechanism Pseudomonas putida
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
naphthalene + NAD(P)H + O2
-
 Pseudomonas putida cis-(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(P)+ only cis-isomer by bacteria, product rapidly autooxidizes to 1,2-naphthoquinone ?
naphthalene + NAD(P)H + O2
-
 Pseudomonas putida 119 cis-(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(P)+ only cis-isomer by bacteria, product rapidly autooxidizes to 1,2-naphthoquinone ?
naphthalene + NADH + O2 initial oxidative reaction in bacterial naphthalene catabolism Pseudomonas putida (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+
-
 ?
naphthalene + NADH + O2 initial oxidative reaction in bacterial naphthalene catabolism Pseudomonas putida 119 (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Pseudomonas putida

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Pseudomonas putida
NADH
-
 Pseudomonas putida
NADPH
-
 Pseudomonas putida