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Literature summary for 1.14.11.9 extracted from

  • Himi, E.; Maekawa, M.; Noda, K.
    Differential expression of three flavanone 3-hydroxylase genes in grains and coleoptiles of wheat (2011), Int. J. Plant Genomics, 2011, 369460.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene F3H-B1 and a fourth gene F3H-B2, a nonhomologous duplication of F3H-B1, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic tree Triticum aestivum
gene F3H-D1, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic tree Triticum aestivum
gene F3HA1, DNA and amiino acid sequence determination and analysis, sequence comparisons and phylogenetic tree, a recognition site of bZIP-type transcription factor (bZIP911) occurs in the promoter of F3H-A1 Triticum aestivum

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required, two histidines and one aspartic acid of the pfam03171 motif are sites for putative iron binding Triticum aestivum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a flavanone + 2-oxoglutarate + O2 Triticum aestivum
-
a dihydroflavonol + succinate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Triticum aestivum C0SPH1 gene F3HA1; diverse wheat lines, F3H gene F3HA1
-
Triticum aestivum C0SPH2 gene F3H-B1; diverse wheat lines, F3H gene F3H-B1, and a fourth gene F3H-B2, a nonhomologous duplication of F3H-B1
-
Triticum aestivum C0SPH3 gene F3H-D1; diverse wheat lines, F3H gene F3H-D1
-

Source Tissue

Source Tissue Comment Organism Textmining
coleoptile
-
Triticum aestivum
-
additional information the F3H gene is highly activated in the red grains and coleoptiles, no expression in white grains Triticum aestivum
-
additional information the F3H gene is highly activated in the red grains and coleoptiles, only slight expression in white grains Triticum aestivum
-
seed
-
Triticum aestivum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a flavanone + 2-oxoglutarate + O2
-
Triticum aestivum a dihydroflavonol + succinate + CO2
-
?

Synonyms

Synonyms Comment Organism
F3H
-
Triticum aestivum
flavanone 3-hydroxylase
-
Triticum aestivum

General Information

General Information Comment Organism
evolution the F3H isozymes have a unique motif of pfam03171 that is maintained in the superfamily of 2-oxoglutarate and Fe(II)-dependent oxygenases Triticum aestivum
metabolism flavanone 3-hydroxylase is a key enzyme at a diverging point of the flavonoid pathway leading to production of different pigments: phlobaphene, proanthocyanidin, and anthocyanin, flavonoid biosynthetic pathway, overview Triticum aestivum
physiological function the enzyme is involved in the red pigmentation of grain tissues, overview Triticum aestivum