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Literature summary for 1.14.11.8 extracted from

  • Henderson, L.M.; Nelson, P.J.; Henderson, L.
    Mammalian enzymes of trimethyllysine conversion to trimethylaminobutyrate (1982), Fed. Proc., 41, 2843-2847.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
dithiothreitol sparing as well as augmenting effect Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
alpha-N-Acetyltrimethyllysine
-
Bos taurus
citrate
-
Bos taurus
Hydroxytrimethyllysine 4 stereoisomers Bos taurus
isocitrate
-
Bos taurus
Lactate
-
Bos taurus
malonate
-
Bos taurus
p-chloromercuribenzoate
-
Bos taurus
succinate
-
Bos taurus
Zn2+
-
Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.13
-
N6,N6,N6-Trimethyl-L-lysine
-
Bos taurus
0.22
-
alpha-ketoglutarate
-
Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Bos taurus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ no stimulation Bos taurus
Fe2+ required Bos taurus
Fe2+ preincubation with Fe2+ in absence of other cofactors inactivates (ascorbate or dithiothreitol prevents inactivation) Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52000
-
x * 52000 + x * 65000, SDS-PAGE Bos taurus
65000
-
x * 52000 + x * 65000, SDS-PAGE Bos taurus
180000
-
gel filtration Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
kidney cortex (67%), medulla (33%) Bos taurus
-
liver
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Bos taurus

Storage Stability

Storage Stability Organism
0°C, half-life: 5 days Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 N6,N6, N6-trimethyl-L-lysine is epsilon-N-trimethyl-L-lysine Bos taurus 3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2
-
?

Subunits

Subunits Comment Organism
? x * 52000 + x * 65000, SDS-PAGE Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Bos taurus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
-
-
half-life: 5 days Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
assay at Bos taurus

Cofactor

Cofactor Comment Organism Structure
ascorbate required Bos taurus