Literature summary for 1.14.11.8 extracted from

Furusawa, H.; Sato, Y.; Tanaka, Y.; Inai, Y.; Amano, A.; Iwama, M.; Kondo, Y.; Handa, S.; Murata, A.; Nishikimi, M.; Goto, S.; Maruyama, N.; Takahashi, R.; Ishigami, A.
Vitamin C is not essential for carnitine biosynthesis in vivo: verification in vitamin C-depleted senescence marker protein-30/gluconolactonase knockout mice (2008), Biol. Pharm. Bull., 31, 1673-1679.

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Activating Compound

Activating Compound	Comment	Organism	Structure
L-ascorbic acid	activates, but is not essentially required	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of senescence marker protein-30/gluconolactonase knockout mice, which cannot synthesize L-ascorbate in vivo, the mutant mice nevertheless produce normal levels of carnitine when fed an L-ascorbate lacking diet	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Mus musculus	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2	Mus musculus	-	3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q91ZE0	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2	-	Mus musculus	3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2	-	?

Synonyms

Synonyms	Comment	Organism
6-N-trimethyllysine dioxygenase	-	Mus musculus
TMLD	-	Mus musculus

General Information

General Information	Comment	Organism
metabolism	the enzyme catalyzes the first step in the biosynthesis of carnitine	Mus musculus

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Release 2023.1 (January 2023)