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Literature summary for 1.14.11.8 extracted from
- Measurement of carnitine biosynthesis enzyme activities by tandem mass spectrometry: differences between the mouse and the rat (2006), Anal. Biochem., 354, 132-139.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | 1 mM, complete inhibition | Mus musculus |  |
| Zn2+ | 1 mM, complete inhibition | Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | absence of the cofactor Fe2+ does not completely abolish enzyme activity, even when endogenous Fe2+ is removed from the homogenate with a gel filtration column | Mus musculus | |
| Fe2+ | absence of the cofactor Fe2+ does not completely abolish enzyme activity, even when endogenous Fe2+ is removed from the homogenate with a gel filtration column | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Mus musculus | - |
| heart | - |
Rattus norvegicus | - |
| kidney | - |
Mus musculus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Rattus norvegicus | - |
| testis | - |
Mus musculus | - |
| testis | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 | - |
Mus musculus | 3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2 | - |
? | |
| N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 | - |
Rattus norvegicus | 3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 6-N-trimethyllysine dioxygenase | - |
Mus musculus |
| 6-N-trimethyllysine dioxygenase | - |
Rattus norvegicus |
| TML dioxygenase | - |
Mus musculus |
| TML dioxygenase | - |
Rattus norvegicus |
| TMLD | - |
Mus musculus |
| TMLD | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ascorbate | 10 mM | Mus musculus | |
| ascorbate | 10 mM | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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