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Literature summary for 1.14.11.7 extracted from
- Partial purification and characterization of chick-embryo prolyl 3-hydroxylase (1979), Biochem. J., 183, 303-307.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| concanavalin A | - |
Gallus gallus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.003 | - |
2-oxoglutarate | - |
Gallus gallus |  |
| 0.03 | - |
O2 | - |
Gallus gallus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | required | Gallus gallus | |
| Fe2+ | Km: 0.002 mM | Gallus gallus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 160000 | - |
gel filtration | Gallus gallus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| procollagen + 2-oxoglutarate + O2 | Gallus gallus | the enzyme catalyzes the synthesis of 3-hydroxyproline in collagen by the hydroxylation of prolyl residues | procollagen trans-3-hydroxy-L-proline + succinate + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Gallus gallus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Gallus gallus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryo | - |
Gallus gallus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Gallus gallus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| procollagen + 2-oxoglutarate + O2 | the enzyme catalyzes the synthesis of 3-hydroxyproline in collagen by the hydroxylation of prolyl residues | Gallus gallus | procollagen trans-3-hydroxy-L-proline + succinate + CO2 | - |
? | |
| protocollagen containing 4-hydroxyproline + 2-oxoglutarate + O2 | - |
Gallus gallus | ? | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ascorbate | required | Gallus gallus | |
| ascorbate | Km: 0.12 mM | Gallus gallus | |
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Release 2023.1 (January 2023)
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