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Literature summary for 1.14.11.4 extracted from

  • Remst, D.F.; Blaney Davidson, E.N.; Vitters, E.L.; Bank, R.A.; van den Berg, W.B.; van der Kraan, P.M.
    TGF-beta induces lysyl hydroxylase 2b in human synovial osteoarthritic fibroblasts through ALK5 signaling (2013), Cell Tissue Res., 355, 163-171.
    View publication on PubMed
Search for more literature for 1.14.11.4

Application

Application Comment Organism
medicine LH2b is an interesting target to interfere with osteoarthritis-related persistent fibrosis Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene PLOD2, encoding for splice variants LH2a and LH2b, quantitative expression analysis of LH2b Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-lysine-[procollagen] + 2-oxoglutarate + O2 Homo sapiens
-
 (2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 gene PLOD2, encoding for splice variants LH2a and LH2b
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast synovial osteoarthritic Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-lysine-[procollagen] + 2-oxoglutarate + O2
-
 Homo sapiens (2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
2-oxoglutarate 5-dioxygenase 2
-
 Homo sapiens
LH2b
-
 Homo sapiens
lysyl hydroxylase 2b
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens in osteoarthritic human synovial fibroblasts, the enzyme expression is induced by TGF-beta via kinase ALK5, not ALK1, and Smad2/3P up

General Information

General Information Comment Organism
metabolism in osteoarthritic human synovial fibroblasts, the enzyme expression is induced by TGF-beta via kinase ALK5, not ALK1, and Smad2/3P Homo sapiens
physiological function lysyl hydroxylases are enzymes that catalyze the hydroxylation of lysine into hydroxylysine and, therefore, fulfill a crucial role in collagen modification and cross-linking. Lysyl hydroxylase 2b increases pyridinoline cross-links, making collagen less susceptible to enzymatic degradation Homo sapiens