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Literature summary for 1.14.11.4 extracted from

  • Walker, L.C.; Overstreet, M.A.; Yeowell, H.N.
    Tissue-specific expression and regulation of the alternatively-spliced forms of lysyl hydroxylase 2 (LH2) in human kidney cells and skin fibroblasts (2005), Matrix Biol., 23, 515-523.
    View publication on PubMed
Search for more literature for 1.14.11.4

Cloned(Commentary)

Cloned (Comment) Organism
genomic structure of isozyme LH2, expression analysis of the 2 splicing variants of isozyme LH2 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the long splicing variant of isozyme LH2 is the major ubiquitously-expressed form that is spliced into the short form, which is expressed together with the long form only in some tissues, e.g. kidney, spleen, liver, and placenta, alternative splicing can be regulated by both cell density and cycloheximide, regulation of LH2long transcript and of expression of both splicing variants in kidney via cycloheximide that suppress a factor taht inhibits exclusion of exon 13A thereby promoting expression of LH2short, and vice versa also via cycloheximide in fibroblasts, overview, perturbation of LH2 regulation can influence the stability of the extracellular matrix and contribute to connective tissue disorders ?
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 ?
procollagen L-lysine + 2-oxoglutarate + O2 Homo sapiens some hydroxylated L-lysine residues are precursors for the cross-link formation essential for the tensile strength of collagen, the 2 splicing variants exhibit different specificity for hydroxylation of either telopeptide or helical collagen domain lysine residues, so that their relative expression level determines the type of cross-links formed and affecting collagen strength procollagen 5-hydroxy-L-lysine + succinate + CO2
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O00469 2 splicing variants of isozyme LH2, termed LH2long and LH2short
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Source Tissue

Source Tissue Comment Organism Textmining
aorta expression only of LH2long Homo sapiens
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cartilage expression of LH2long and LH2short Homo sapiens
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dura expression only of LH2long Homo sapiens
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fibroblast of skin, expression only of LH2long Homo sapiens
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HEK-293 cell expression of LH2long and LH2short Homo sapiens
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kidney expression of LH2long and LH2short Homo sapiens
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liver expression of LH2long and LH2short Homo sapiens
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lung expression only of LH2long Homo sapiens
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additional information the long splicing variant of isozyme LH2 is the major ubiquitously-expressed form that is spliced into the short form, which is expressed together with the long form only in some tissues, e.g. kidney, cartilage, spleen, liver, and placenta, not in skin, lung, aorta, and dura Homo sapiens
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placenta expression of LH2long and LH2short Homo sapiens
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skin expression only of LH2long Homo sapiens
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spleen expression of LH2long and LH2short Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the long splicing variant of isozyme LH2 is the major ubiquitously-expressed form that is spliced into the short form, which is expressed together with the long form only in some tissues, e.g. kidney, spleen, liver, and placenta, alternative splicing can be regulated by both cell density and cycloheximide, regulation of LH2long transcript and of expression of both splicing variants in kidney via cycloheximide that suppress a factor taht inhibits exclusion of exon 13A thereby promoting expression of LH2short, and vice versa also via cycloheximide in fibroblasts, overview, perturbation of LH2 regulation can influence the stability of the extracellular matrix and contribute to connective tissue disorders Homo sapiens ?
-
 ?
procollagen L-lysine + 2-oxoglutarate + O2
-
 Homo sapiens procollagen 5-hydroxy-L-lysine + succinate + CO2
-
 ?
procollagen L-lysine + 2-oxoglutarate + O2 some hydroxylated L-lysine residues are precursors for the cross-link formation essential for the tensile strength of collagen, the 2 splicing variants exhibit different specificity for hydroxylation of either telopeptide or helical collagen domain lysine residues, so that their relative expression level determines the type of cross-links formed and affecting collagen strength Homo sapiens procollagen 5-hydroxy-L-lysine + succinate + CO2
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 ?

Synonyms

Synonyms Comment Organism
LH
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 Homo sapiens
lysyl hydroxylase
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 Homo sapiens