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Literature summary for 1.14.11.4 extracted from

  • Samimi, A.; Last, J.A.
    Mechanism of inhibition of lysyl hydroxylase activity by the organophosphates malathion and malaoxon (2001), Toxicol. Appl. Pharmacol., 176, 181-186.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in insect cells using a baculovirus vector Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
malaoxon mechanism of inhibition Rattus norvegicus
malathion mechanism of inhibition Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
85000
-
x * 85000, SDS-PAGE and Western blotting Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
collagen + 2-oxoglutarate + O2 Rattus norvegicus enzyme required during collagen biosynthesis 5-hydroxylysyl-collagen + succinate + CO2
-
?
collagen + 2-oxoglutarate + O2 Rattus norvegicus influence the integrity and stability of collagen 5-hydroxylysyl-collagen + succinate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q63321
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification hydroxylation of lysyl residue in -X-Lys-Gly Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
collagen + 2-oxoglutarate + O2 enzyme required during collagen biosynthesis Rattus norvegicus 5-hydroxylysyl-collagen + succinate + CO2
-
?
collagen + 2-oxoglutarate + O2 influence the integrity and stability of collagen Rattus norvegicus 5-hydroxylysyl-collagen + succinate + CO2
-
?
peptidyl-L-lysine + 2-oxoglutarate + O2
-
Rattus norvegicus peptidyl-5-hydroxy-L-lysine + succinate + CO2 hydroxy-L-lysine ?

Subunits

Subunits Comment Organism
? x * 85000, SDS-PAGE and Western blotting Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.047
-
malaoxon
-
Rattus norvegicus
0.059
-
malathion
-
Rattus norvegicus