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Literature summary for 1.14.11.33 extracted from
- AlkB mystery solved: oxidative demethylation of N1-methyladenine and N3-methylcytosine adducts by a direct reversal mechanism (2003), Trends Biochem. Sci., 28, 2-5.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | - |
Escherichia coli |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | non-heme Fe2+ is required for activity | Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA-1-methyladenine + 2-oxoglutarate + O2 | this reaction occurs on both single- and double-stranded DNA | Escherichia coli | DNA-adenine + formaldehyde + succinate + CO2 | - |
? | |
| DNA-3-methylcytosine + 2-oxoglutarate + O2 | this reaction occurs on both single- and double-stranded DNA | Escherichia coli | DNA-cytosine + formaldehyde + succinate + CO2 | - |
? | |
| additional information | AlkB preferentially binds and reactivates methylated single-stranded DNA | Escherichia coli | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AlkB | - |
Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| 2-oxoglutarate | - |
Escherichia coli | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the alkB gene product protects against cell killing by SN2-alkylating agents, probably through DNA repair | Escherichia coli |
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Release 2023.1 (January 2023)
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