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Literature summary for 1.14.11.33 extracted from

  • Falnes, P.O.; Johansen, R.F.; Seeberg, E.
    AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli (2002), Nature, 419, 178-182.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 Star(DE3)pLysS cells Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required for activity Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli W3110 / ATCC 27325
-
-
-

Purification (Commentary)

Purification (Comment) Organism
GSTrap column chromatography Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA-1-methyladenine + 2-oxoglutarate + O2
-
Escherichia coli DNA-adenine + formaldehyde + succinate + CO2
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
-
Escherichia coli W3110 / ATCC 27325 DNA-adenine + formaldehyde + succinate + CO2
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
-
Escherichia coli DNA-cytosine + formaldehyde + succinate + CO2
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
-
Escherichia coli W3110 / ATCC 27325 DNA-cytosine + formaldehyde + succinate + CO2
-
?
methylated single-stranded poly(deoxyadenosine) + 2-oxoglutarate + O2
-
Escherichia coli single-stranded poly(deoxyadenosine) + formaldehyde + succinate + CO2
-
?
methylated single-stranded poly(deoxyadenosine) + 2-oxoglutarate + O2
-
Escherichia coli W3110 / ATCC 27325 single-stranded poly(deoxyadenosine) + formaldehyde + succinate + CO2
-
?
additional information although the lesions targeted by AlkB are introduced primarily into single-stranded DNA, AlkB is also capable of removing lesions from double-stranded DNA Escherichia coli ?
-
?
additional information although the lesions targeted by AlkB are introduced primarily into single-stranded DNA, AlkB is also capable of removing lesions from double-stranded DNA Escherichia coli W3110 / ATCC 27325 ?
-
?

Synonyms

Synonyms Comment Organism
AlkB
-
Escherichia coli

Cofactor

Cofactor Comment Organism Structure
2-oxoglutarate
-
Escherichia coli

General Information

General Information Comment Organism
physiological function AlkB-mediated oxidative demethylation reverses DNA damage Escherichia coli