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Literature summary for 1.14.11.33 extracted from

  • Trewick, S.C.; Henshaw, T.F.; Hausinger, R.P.; Lindahl, T.; Sedgwick, B.
    Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage (2002), Nature, 419, 174-178.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required for activity Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA-1-methyladenine + 2-oxoglutarate + O2 purified AlkB repairs the cytotoxic lesion 1-methyladenine in single- and double-stranded DNA Escherichia coli DNA-adenine + formaldehyde + succinate + CO2
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2 purified AlkB repairs the cytotoxic lesion 3-methylcytosine in single- and double-stranded DNA Escherichia coli DNA-cytosine + formaldehyde + succinate + CO2
-
?
methylated poly(deoxyadenine) + 2-oxoglutarate + O2 0.1 pmol AlkB protein removes 1.7 pmol 1-methyladenine from methylated poly(deoxyadenine) in 15 min Escherichia coli poly(deoxyadenine) + formaldehyde + succinate + CO2
-
?
methylated poly(deoxycytosine) + 2-oxoglutarate + O2
-
Escherichia coli poly(deoxycytosine) + formaldehyde + succinate + CO2
-
?
additional information AlkB has no detectable nuclease, DNA glycosylase or methyltransferase activity Escherichia coli ?
-
?

Synonyms

Synonyms Comment Organism
AlkB
-
Escherichia coli

Cofactor

Cofactor Comment Organism Structure
2-oxoglutarate
-
Escherichia coli

General Information

General Information Comment Organism
malfunction Escherichia coli alkB mutants are defective in processing methylation damage generated in single-stranded DNA Escherichia coli
physiological function oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage Escherichia coli