Literature summary for 1.14.11.31 extracted from

Kachhap, S.; Wojdyla, Z.; Komorek, P.; Kluza, A.; Kurpiewska, K.; Jachimska, B.; Borowski, T.
It takes two to tango - The case of thebaine 6-O-demethylase (2020), Int. J. Biol. Macromol., 163, 718-729 .

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Organism

Organism	UniProt	Comment	Textmining
Papaver somniferum	D4N500	-	-

General Information

General Information	Comment	Organism
metabolism	the enzyme-substrate complex of T6ODM has a 1:2 stoichiometry. The key residues responsible for substrate binding are Val128, Glu133, Met150 and Agr219 for the substrate in the distal position, and Asp144, Leu235 and Leu353 for the proximal substrate molecule. Tthe oxo ligand is bound trans to His295 and the enzyme catalyzes hydroxylation of the C6-bound methoxy group according to the established rebound mechanism. The final stage of the demethylation reaction includes deformylation and enol-keton tautomerization steps and is most likely catalyzed by water molecules and takes place in the solvent	Papaver somniferum

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Release 2023.1 (January 2023)