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Literature summary for 1.14.11.27 extracted from

  • Fang, J.; Hogan, G.J.; Liang, G.; Lieb, J.D.; Zhang, Y.
    The Saccharomyces cerevisiae histone demethylase Jhd1 fine-tunes the distribution of H3K36me2 (2007), Mol. Cell. Biol., 27, 5055-5065.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.27

Activating Compound

Activating Compound Comment Organism Structure
ascorbate stimulation Saccharomyces cerevisiae

Cloned(Commentary)

Cloned (Comment) Organism
expression of Flag-tagged protein Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
H305A more than 90% loss of activity Saccharomyces cerevisiae
additional information overexpression results in moderate decrease in dimethyl-histone 3 L-lysine 36 and a slight decrease in trimethyl-histone 3 L-lysine 36 along with unaltered methyl-histone 3 L-lysine 36 levels. Deletion of the N-terminal PHD domain leads to about 50% decrease in activity. Deletion of C-terminal 125, 193, or 244 amino acids results in more than 90% loss of activity Saccharomyces cerevisiae
T302A more than 90% loss of activity Saccharomyces cerevisiae
Y315A more than 90% loss of activity Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Iron Fe2+ is required Saccharomyces cerevisiae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
56500
-
 x * 56500, calculated Saccharomyces cerevisiae
250000
-
 gel filtration Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P40034 histone demethylase Jhd1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dimethyl-histone 3 L-lysine 36 + 2-oxoglutarate + O2
-
 Saccharomyces cerevisiae methyl-histone 3 L-lysine 36 + succinate + formaldehyde + CO2
-
 ?
additional information no substrate: methyl-histone 3 L-lysine 4, histone 3 L-lysine 79 Saccharomyces cerevisiae ?
-
 ?

Subunits

Subunits Comment Organism
oligomer x * 56500, calculated Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
Jhd1
-
 Saccharomyces cerevisiae
JmjC domain-containing histone demethylase 1
-
 Saccharomyces cerevisiae