Cloned (Comment) | Organism |
---|---|
isozymes CAS1 and CAS2 encoded by genes cas1 and cas2, respectively, genetic analysis | Streptomyces clavuligerus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a disruption mutant of isozyme cas2 by a gene replacement procedure, mutant shows no activity in starch-asparagine medium, but reduced activity, compared to the wild-type, in soy medium which is due to CAS1 isozyme, different regulation of the 2 isozymes concerning nutritional conditions | Streptomyces clavuligerus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxyamidinoproclavaminate + 2-oxoglutarate + O2 | Streptomyces clavuligerus | this reaction is due to a proclavaminate amidinohydrolase, i.e. cla | amidinoproclavaminate + succinate + CO2 + H2O | - |
? | |
deoxyamidinoproclavaminate + 2-oxoglutarate + O2 | Streptomyces clavuligerus NRRL 3585 | this reaction is due to a proclavaminate amidinohydrolase, i.e. cla | amidinoproclavaminate + succinate + CO2 + H2O | - |
? | |
dihydroclavaminate + 2-oxoglutarate + O2 | Streptomyces clavuligerus | - |
clavaminate + succinate + CO2 + H2O | - |
? | |
additional information | Streptomyces clavuligerus | enzyme plays a critical role in the biosynthesis of the clavam metabolites | ? | - |
? | |
additional information | Streptomyces clavuligerus | biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor | ? | - |
? | |
additional information | Streptomyces clavuligerus NRRL 3585 | enzyme plays a critical role in the biosynthesis of the clavam metabolites | ? | - |
? | |
additional information | Streptomyces clavuligerus NRRL 3585 | biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor | ? | - |
? | |
proclavaminate + 2-oxoglutarate + O2 | Streptomyces clavuligerus | - |
dihydroclavaminate + succinate + CO2 + H2O | - |
? | |
proclavaminate + 2-oxoglutarate + O2 | Streptomyces clavuligerus NRRL 3585 | - |
dihydroclavaminate + succinate + CO2 + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces clavuligerus | - |
- |
- |
Streptomyces clavuligerus | - |
2 isozymes CAS1 and CAS2, encoded by genes cas1 and cas2, respectively | - |
Streptomyces clavuligerus NRRL 3585 | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2 | this reaction is due to a proclavaminate amidinohydrolase PAH, gene cla | Streptomyces clavuligerus | |
dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + H2O | reaction mechanism | Streptomyces clavuligerus | |
proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + H2O | reaction mechanism | Streptomyces clavuligerus |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
activity of wild-type and mutant in different growth media | Streptomyces clavuligerus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxyamidinoproclavaminate + 2-oxoglutarate + O2 | this reaction is due to a proclavaminate amidinohydrolase, i.e. cla | Streptomyces clavuligerus | amidinoproclavaminate + succinate + CO2 + H2O | - |
? | |
deoxyamidinoproclavaminate + 2-oxoglutarate + O2 | this reaction is due to a proclavaminate amidinohydrolase, i.e. cla | Streptomyces clavuligerus NRRL 3585 | amidinoproclavaminate + succinate + CO2 + H2O | - |
? | |
dihydroclavaminate + 2-oxoglutarate + O2 | - |
Streptomyces clavuligerus | clavaminate + succinate + CO2 + H2O | - |
? | |
dihydroclavaminate + 2-oxoglutarate + O2 | cyclization | Streptomyces clavuligerus | clavaminate + succinate + CO2 + H2O | - |
? | |
additional information | enzyme plays a critical role in the biosynthesis of the clavam metabolites | Streptomyces clavuligerus | ? | - |
? | |
additional information | biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor | Streptomyces clavuligerus | ? | - |
? | |
additional information | enzyme plays a critical role in the biosynthesis of the clavam metabolites | Streptomyces clavuligerus NRRL 3585 | ? | - |
? | |
additional information | biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor | Streptomyces clavuligerus NRRL 3585 | ? | - |
? | |
proclavaminate + 2-oxoglutarate + O2 | - |
Streptomyces clavuligerus | dihydroclavaminate + succinate + CO2 + H2O | - |
? | |
proclavaminate + 2-oxoglutarate + O2 | saturation | Streptomyces clavuligerus | dihydroclavaminate + succinate + CO2 + H2O | - |
? | |
proclavaminate + 2-oxoglutarate + O2 | - |
Streptomyces clavuligerus NRRL 3585 | dihydroclavaminate + succinate + CO2 + H2O | - |
? | |
proclavaminate + 2-oxoglutarate + O2 | saturation | Streptomyces clavuligerus NRRL 3585 | dihydroclavaminate + succinate + CO2 + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CAS | - |
Streptomyces clavuligerus |