Literature summary for 1.14.11.2 extracted from

Duran, R.V.; MacKenzie, E.D.; Boulahbel, H.; Frezza, C.; Heiserich, L.; Tardito, S.; Bussolati, O.; Rocha, S.; Hall, M.N.; Gottlieb, E.
HIF-independent role of prolyl hydroxylases in the cellular response to amino acids (2013), Oncogene, 32, 4549-4556.

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Inhibitors

Inhibitors	Comment	Organism	Structure
cobalt chloride	inhibition of PHDs blocks the response of mTORC1 to amino acids	Homo sapiens
dimethyloxallyl glycine	inhibition of PHDs blocks the response of mTORC1 to amino acids	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HCT-116 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PHD	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	pharmacologic or genetic inhibition of PHDs induces autophagy and prevents mammalian target of rapamycin complex 1 (mTORC1) activation by amino acids in a HIF-independent manner	Homo sapiens
metabolism	amino-acid starvation causes depletion of alpha-ketoglutarate that leads to PHD inactivation	Homo sapiens

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Release 2023.1 (January 2023)