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BRENDA support

Literature summary for 1.14.11.2 extracted from

  • Chen, R.L.; Nagel, S.; Papadakis, M.; Bishop, T.; Pollard, P.; Ratcliffe, P.J.; Pugh, C.W.; Buchan, A.M.
    Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice (2012), J. Physiol., 590, 4079-4091.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
PHD1
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Mus musculus
PHD2
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Mus musculus

General Information

General Information Comment Organism
malfunction PHD1-/- mice have statistically non-significant reductions in infarct volumes following middle cerebral artery occlusion compared with their littermates at this time-point in this model Mus musculus
malfunction PHD2+/- mice have significantly increased microvessel density, improved cerebral blood flow on reperfusion, and show significantly better functional outcomes and higher locomotor activity associated with significantly fewer apoptotic cells in the penumbra and significantly less blood-brain-barrier disruption with a trend to reduced infarct volumes 24 h after the middle cerebral artery occlusion than littermate controls Mus musculus