Application | Comment | Organism |
---|---|---|
diagnostics | activation of NF-kappaB is observed in colon cancer. PHD3 appears to be a tumor suppressor in colorectal cancer cells that inhibits IKKbeta/NF-kappaB signaling. Determination of PHD3 status could aid targeted therapy selection for patients with colorectal tumors that have increased NF-kappaB activity | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
determination of PHD3 mRNA by real-time PCR | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
procollagen L-proline + 2-oxoglutarate + O2 | Homo sapiens | - |
procollagen trans-4-hydroxy-L-proline + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colorectal carcinoma cell | 60 primary colorectal carcinoma tissues, PHD expression analysis, overview. expression of PHD3 is decreased in colorectal cancer, which is associated with higher tumor grade and metastasis, while expression of PHD1 is increased in colorectal tumors. Expression of PHD2 of colorectal tumors is similar to that of paired healthy colorectal tissues | Homo sapiens | - |
colorectum | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
SW-480 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
procollagen L-proline + 2-oxoglutarate + O2 | - |
Homo sapiens | procollagen trans-4-hydroxy-L-proline + succinate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
hypoxia inducible factor-prolyl hydroxylase | - |
Homo sapiens |
PHD1 | - |
Homo sapiens |
PHD2 | - |
Homo sapiens |
PHD3 | - |
Homo sapiens |
prolyl hydroxylase-3 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | PHD3 appears to be a tumor suppressor in colorectal cancer cells that inhibits IKKbeta/NF-kappaB signaling, independent of its hydroxylase activity | Homo sapiens |