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Literature summary for 1.14.11.2 extracted from

  • Xue, J.; Li, X.; Jiao, S.; Wei, Y.; Wu, G.; Fang, J.
    Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity (2010), Gastroenterology, 138, 606-615.
    View publication on PubMed

Application

Application Comment Organism
diagnostics activation of NF-kappaB is observed in colon cancer. PHD3 appears to be a tumor suppressor in colorectal cancer cells that inhibits IKKbeta/NF-kappaB signaling. Determination of PHD3 status could aid targeted therapy selection for patients with colorectal tumors that have increased NF-kappaB activity Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
determination of PHD3 mRNA by real-time PCR Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
procollagen L-proline + 2-oxoglutarate + O2 Homo sapiens
-
procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colorectal carcinoma cell 60 primary colorectal carcinoma tissues, PHD expression analysis, overview. expression of PHD3 is decreased in colorectal cancer, which is associated with higher tumor grade and metastasis, while expression of PHD1 is increased in colorectal tumors. Expression of PHD2 of colorectal tumors is similar to that of paired healthy colorectal tissues Homo sapiens
-
colorectum
-
Homo sapiens
-
HCT-116 cell
-
Homo sapiens
-
SW-480 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
procollagen L-proline + 2-oxoglutarate + O2
-
Homo sapiens procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
?

Synonyms

Synonyms Comment Organism
hypoxia inducible factor-prolyl hydroxylase
-
Homo sapiens
PHD1
-
Homo sapiens
PHD2
-
Homo sapiens
PHD3
-
Homo sapiens
prolyl hydroxylase-3
-
Homo sapiens

General Information

General Information Comment Organism
physiological function PHD3 appears to be a tumor suppressor in colorectal cancer cells that inhibits IKKbeta/NF-kappaB signaling, independent of its hydroxylase activity Homo sapiens