Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.2 extracted from

  • Villar, D.; Vara-Vega, A.; Landazuri, M.O.; Del Peso, L.
    Identification of a region on hypoxia-inducible-factor prolyl 4-hydroxylases that determines their specificity for the oxygen degradation domains (2007), Biochem. J., 408, 231-240.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information generation of chimaeric constructs by swapping the regions of isoforms EGLN1 and EGLN3 Homo sapiens
additional information generation of chimaeric constructs by swapping the regions of isoforms EGLN1 and EGLN3. A minimal sequence of residues 236-252 of EGLN1 is involved in substrate discrimination Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96KS0 isoform EGLN2
-
Homo sapiens Q9GZT9 isoform EGLN1
-
Homo sapiens Q9H6Z9 isoform EGLN3
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hypoxia-inducible factor alpha L-proline + 2-oxoglutarate + O2 isoform EGLN1 acts upon both the N-and the C-terminal oxygen-dependent degradation domain to target hypoxia-inducible factor alpha for proteasomal degradation Homo sapiens hypoxia-inducible factor alpha trans-4-hydroxy-L-proline + succinate + CO2
-
?
hypoxia-inducible factor alpha L-proline + 2-oxoglutarate + O2 isoform EGLN2 acts upon both the N-and the C-terminal oxygen-dependent degradation domain to target hypoxia-inducible factor alpha for proteasomal degradation Homo sapiens hypoxia-inducible factor alpha trans-4-hydroxy-L-proline + succinate + CO2
-
?
hypoxia-inducible factor alpha L-proline + 2-oxoglutarate + O2 isoform EGLN3 acts on the N-terminal oxygen-dependent degradation domain Homo sapiens hypoxia-inducible factor alpha trans-4-hydroxy-L-proline + succinate + CO2
-
?

Subunits

Subunits Comment Organism
More a minimal sequence of residues 236-252 of EGLN1 is involved in substrate discrimination Homo sapiens

Synonyms

Synonyms Comment Organism
Egl nine homolog
-
Homo sapiens
EGLN
-
Homo sapiens