Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of chimaeric constructs by swapping the regions of isoforms EGLN1 and EGLN3 | Homo sapiens |
additional information | generation of chimaeric constructs by swapping the regions of isoforms EGLN1 and EGLN3. A minimal sequence of residues 236-252 of EGLN1 is involved in substrate discrimination | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q96KS0 | isoform EGLN2 | - |
Homo sapiens | Q9GZT9 | isoform EGLN1 | - |
Homo sapiens | Q9H6Z9 | isoform EGLN3 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hypoxia-inducible factor alpha L-proline + 2-oxoglutarate + O2 | isoform EGLN1 acts upon both the N-and the C-terminal oxygen-dependent degradation domain to target hypoxia-inducible factor alpha for proteasomal degradation | Homo sapiens | hypoxia-inducible factor alpha trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
hypoxia-inducible factor alpha L-proline + 2-oxoglutarate + O2 | isoform EGLN2 acts upon both the N-and the C-terminal oxygen-dependent degradation domain to target hypoxia-inducible factor alpha for proteasomal degradation | Homo sapiens | hypoxia-inducible factor alpha trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
hypoxia-inducible factor alpha L-proline + 2-oxoglutarate + O2 | isoform EGLN3 acts on the N-terminal oxygen-dependent degradation domain | Homo sapiens | hypoxia-inducible factor alpha trans-4-hydroxy-L-proline + succinate + CO2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | a minimal sequence of residues 236-252 of EGLN1 is involved in substrate discrimination | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Egl nine homolog | - |
Homo sapiens |
EGLN | - |
Homo sapiens |