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Literature summary for 1.14.11.2 extracted from

  • Kukkola, L.; Hieta, R.; Kivirikko, K.I.; Myllyharju, J.
    Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme (2003), J. Biol. Chem., 278, 47685-47693.
    View publication on PubMed
Search for more literature for 1.14.11.2

Activating Compound

Activating Compound Comment Organism Structure
ascorbate required for activity Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
 Rattus norvegicus
-
 Mus musculus
expression in insect cells and HEK-293 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
poly(L-Pro) 0.03 mM, 50% inhibition Homo sapiens
Pyridine-2,4-dicarboxylate 0.011 mM, 50% inhibition Homo sapiens
Pyridine-2,5-dicarboxylate 0.007 mM, 50% inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0005
-
 Fe2+
-
 Homo sapiens
0.02
-
 2-oxoglutarate
-
 Homo sapiens
0.024
-
 (Pro-Pro-Gly)10
-
 Homo sapiens
0.37
-
 ascorbate
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required for activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
procollagen L-proline + 2-oxoglutarate + O2 Homo sapiens
-
 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
procollagen L-proline + 2-oxoglutarate + O2 Rattus norvegicus
-
 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
procollagen L-proline + 2-oxoglutarate + O2 Mus musculus
-
 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q7Z4N8
-
-
Mus musculus Q6W3F0
-
-
Rattus norvegicus Q6W3E9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver adult Homo sapiens
-
placenta
-
 Homo sapiens
-
skin fetal Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(Pro-Pro-Gly)10 + 2-oxoglutarate + O2
-
 Homo sapiens trans-4-hydroxy-L-proline (Pro-Pro-Gly)10 + succinate + CO2
-
 ?
2-oxoglutarate + O2 + ascorbate
-
 Homo sapiens succinate + dehydroascorbate + CO2 + H2O
-
 ?
procollagen L-proline + 2-oxoglutarate + O2
-
 Homo sapiens procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
procollagen L-proline + 2-oxoglutarate + O2
-
 Rattus norvegicus procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
procollagen L-proline + 2-oxoglutarate + O2
-
 Mus musculus procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?

Subunits

Subunits Comment Organism
tetramer probably a alpha(III)2, PDI2 tetramer Homo sapiens

Synonyms

Synonyms Comment Organism
C-P4H alpha subunit (III)
-
 Homo sapiens
C-P4H alpha(III)
-
 Rattus norvegicus
C-P4H alpha(III)
-
 Mus musculus