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Literature summary for 1.14.11.2 extracted from
- Prolyl 3-hydroxylase and 4-hydroxylase activities in certain rat and chick-embryo tissues and age-related changes in their activities in the rat (1979), Biochem. J., 178, 127-131.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
- |
- |
| Rattus norvegicus | - |
Sprague-Dawley strain | - |
| Rattus norvegicus Sprague-Dawley | - |
Sprague-Dawley strain | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| aorta | embryo | Gallus gallus | - |
| bone | embryo | Gallus gallus | - |
| cartilage | embryo | Gallus gallus | - |
| cranium | embryo | Gallus gallus | - |
| embryo | - |
Gallus gallus | - |
| femur | embryo, high enzyme activity | Gallus gallus | - |
| heart | embryo | Gallus gallus | - |
| kidney | - |
Gallus gallus | - |
| kidney | - |
Rattus norvegicus | - |
| lens | embryo, lowest enzyme activity | Gallus gallus | - |
| liver | - |
Gallus gallus | - |
| liver | lowest enzyme activity | Rattus norvegicus | - |
| lung | - |
Gallus gallus | - |
| lung | highest enzyme activity | Rattus norvegicus | - |
| additional information | the enzyme activity decreases with age in all the tissues studied | Rattus norvegicus | - |
| skin | embryo | Gallus gallus | - |
| skin | highest enzyme activity | Rattus norvegicus | - |
| sternum | embryo, high enzyme activity | Gallus gallus | - |
| tendon | embryo, highest activity | Gallus gallus | - |
| tibia | embryo, high enzyme activity | Gallus gallus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| procollagen L-proline + 2-oxoglutarate + O2 | - |
Gallus gallus | procollagen trans-4-hydroxy-L-proline + succinate + CO2 | - |
? |  |
| procollagen L-proline + 2-oxoglutarate + O2 | - |
Rattus norvegicus | procollagen trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
| procollagen L-proline + 2-oxoglutarate + O2 | - |
Rattus norvegicus Sprague-Dawley | procollagen trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Gallus gallus |
| 37 | - |
assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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