Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.2 extracted from

  • Takeda, K.; Katoh, F.; Kawai, S.; Konno, K.
    Stimulation of prolyl hydroxylase activity by chelating agents (1979), Arch. Biochem. Biophys., 197, 273-276.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
1,10-phenanthroline stimulates if it reaches an equimolar concentration with Fe2+ Rattus norvegicus
8-hydroxyquinoline stimulates if it reaches an equimolar concentration with Fe2+ Rattus norvegicus
alpha,alpha'-dipyridyl stimulates if it reaches an equimolar concentration with Fe2+ Rattus norvegicus
catalase activation Rattus norvegicus
Diethylenetriaminepentaacetic acid 5fold stimulation at 0.2 mM, equimolar with Fe2+ Rattus norvegicus
EDTA 1.4fold stimulation at 0.2 mM, equimolar with Fe2+ Rattus norvegicus
glycoletherdiamine tetraacetic acid 1.4fold stimulation at 0.2 mM, equimolar with Fe2+, and 2.8fold stimulation at 1 mM Rattus norvegicus
N-Hydroxyethylenediaminetriacetic acid 5fold stimulation at 0.2 mM, equimolar with Fe2+ Rattus norvegicus
nitrilotriacetic acid 6fold stimulation at 0.2 mM, equimolar with Fe2+, and 7.6fold stimulation at 1 mM Rattus norvegicus
nucleoside triphosphates stimulate Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline inhibits at a concentration higher than the Fe2+ concentration in the reaction mixture Rattus norvegicus
2,2'-dipyridyl inhibits at a concentration higher than the Fe2+ concentration in the reaction mixture Rattus norvegicus
8-hydroxyquinoline inhibits at a concentration higher than the Fe2+ concentration in the reaction mixture Rattus norvegicus
Diethylenetriaminepentaacetic acid inhibits at a concentration higher than the Fe2+ concentration in the reaction mixture Rattus norvegicus
EDTA inhibits at a concentration higher than the Fe2+ concentration in the reaction mixture Rattus norvegicus
N-Hydroxyethylenediaminetriacetic acid inhibits at a concentration higher than the Fe2+ concentration in the reaction mixture Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
using ammonium sulfate fractionation and affinity chromatography Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
fetus
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
procollagen L-proline + 2-oxoglutarate + O2
-
Rattus norvegicus procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
2-oxoglutarate
-
Rattus norvegicus