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Literature summary for 1.14.11.2 extracted from

  • Atreya, P.L.; Ananthanarayanan, V.S.
    Interaction of prolyl 4-hydroxylase with synthetic peptide substrates. A conformational model for collagen proline hydroxylation (1991), J. Biol. Chem., 266, 2852-2858.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
bovine serum albumin activation Gallus gallus
catalase activation Gallus gallus
dithiothreitol activation Gallus gallus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
10.7
-
tert-butyloxycarbonyl-Val-Pro-Gly-Val-OH
-
Gallus gallus
22.2
-
tert-butyloxycarbonyl-Gly-Val-Pro-Gly-Val-OH
-
Gallus gallus
24
-
tert-butyloxycarbonyl-Pro-Pro-Ala-Pro-OH
-
Gallus gallus
32.2
-
tert-butyloxycarbonyl-Pro-Pro-Gln-Pro-OCH3
-
Gallus gallus
37.2
-
tert-butyloxycarbonyl-L-Pro-L-Pro-Gly
-
Gallus gallus
37.4
-
tert-butyloxycarbonyl-Pro-Pro-Gly-Pro-Pro-OH
-
Gallus gallus
38.9
-
tert-butyloxycarbonyl-Pro-Pro-Gly-Pro-OH
-
Gallus gallus

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+
-
Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
using affinity chromatography, ion-exchange chromatography and gel filtration Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(Pro-Pro-Gly)n + 2-oxoglutarate + O2 n: 1,5,10 Gallus gallus (Pro-4-hydroxy-Pro-Gly)n + succinate + CO2 n: 1,5,10 ?
(Pro-Pro-Gly)n + 2-oxoglutarate + O2 structural requirement for proline hydroxylation in collagen and related peptides: supersecondary structure, consisting of PP-II followed by a beta-turn, as the conformational determinant for proline hydroxylation in nascent collagen and related substrates of the enzyme, in elastin peptides, the beta-structure appears to substitute for the PP-II structure Gallus gallus (Pro-4-hydroxy-Pro-Gly)n + succinate + CO2 n: 1,5,10 ?
proline containing peptide + 2-oxoglutarate + O2 synthetic peptides Gallus gallus 4-hydroxyproline containing peptide + succinate + CO2
-
?
tert-butyloxycarbonyl-Gly-Val-Pro-Gly-Val-OH + 2-oxoglutarate + O2
-
Gallus gallus tert-butyloxycarbonyl-Gly-Val-Hyp-Gly-Val-OH + succinate + CO2
-
?
tert-butyloxycarbonyl-L-Pro-L-Pro-Gly + 2-oxoglutarate + O2
-
Gallus gallus tert-butyloxycarbonyl-L-Pro-L-Pro-Gly-trans-4-hydroxy-L-proline + succinate + CO2
-
r
tert-butyloxycarbonyl-Pro-Pro-Ala-Pro-OH + 2-oxoglutarate + O2
-
Gallus gallus 4-hydroxyproline containing peptide + succinate + CO2
-
?
tert-butyloxycarbonyl-Pro-Pro-Gln-Pro-OCH3 + 2-oxoglutarate + O2
-
Gallus gallus 4-hydroxyproline containing peptide + succinate + CO2
-
?
tert-butyloxycarbonyl-Pro-Pro-Gly-Pro + 2-oxoglutarate + O2
-
Gallus gallus 4-hydroxyproline containing peptide + succinate + CO2
-
?
tert-butyloxycarbonyl-Pro-Pro-Gly-Pro-NHCH3 + 2-oxoglutarate + O2
-
Gallus gallus 4-hydroxyproline containing peptide + succinate + CO2
-
?
tert-butyloxycarbonyl-Pro-Pro-Gly-Pro-Pro-OH + 2-oxoglutarate + O2
-
Gallus gallus 4-hydroxyproline containing peptide + succinate + CO2
-
?
tert-butyloxycarbonyl-Val-Pro-Gly-Val-OH + 2-oxoglutarate + O2
-
Gallus gallus tert-butyloxycarbonyl-Val-Hyp-Gly-Val-OH + succinate + CO2
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Gallus gallus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.07
-
tert-butyloxycarbonyl-Pro-Pro-Gln-Pro-OCH3
-
Gallus gallus
0.11
-
tert-butyloxycarbonyl-Pro-Pro-Ala-Pro-OH
-
Gallus gallus
0.2
-
tert-butyloxycarbonyl-Pro-Pro-Gly-Pro
-
Gallus gallus
0.38
-
tert-butyloxycarbonyl-Pro-Pro-Gly-Pro-NHCH3
-
Gallus gallus
0.79
-
tert-butyloxycarbonyl-Pro-Pro-Gly-Pro-Pro-OH
-
Gallus gallus
0.88
-
tert-butyloxycarbonyl-Val-Pro-Gly-Val-OH
-
Gallus gallus
2.33
-
tert-butyloxycarbonyl-Gly-Val-Pro-Gly-Val-OH
-
Gallus gallus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Gallus gallus

Cofactor

Cofactor Comment Organism Structure
ascorbate
-
Gallus gallus