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Literature summary for 1.14.11.18 extracted from

  • Croes, K.; Foulon, V.; Casteels, M.; Van Veldhoven, P.P.; Mannaerts, G.P.
    Phytanoyl-CoA hydroxylase: recognition of 3-methyl-branched acyl-CoAs and requirement for GTP or ATP and Mg2+ in addition to its known hydroxylation cofactors (2000), J. Lipid Res., 41, 629-636.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
in bacterial expression vector pQE-31 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-methylhexadecanoyl-CoA 56% of control activity Homo sapiens
hexadecanoyl-CoA 74% of control activity Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ requirement Homo sapiens
Fe2+ requirement Rattus norvegicus
Mg2+
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
human
-
Rattus norvegicus
-
rat
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-methylhexadecanoyl-CoA + 2-oxoglutarate + O2
-
Homo sapiens 2-hydroxy-3-methylhexadecanoyl-CoA + succinate + CO2
-
?
3-methylhexadecanoyl-CoA + 2-oxoglutarate + O2
-
Rattus norvegicus 2-hydroxy-3-methylhexadecanoyl-CoA + succinate + CO2
-
?
phytanoyl-CoA + 2-oxoglutarate + O2
-
Rattus norvegicus alpha-hydroxyphytanoyl-CoA + succinate + CO2
-
?
phytanoyl-CoA + 2-oxoglutarate + O2 no activity with octadecanoyl-CoA, lignoceroyl-CoA, 2-methylhexadecanoyl-CoA and 4,8,12-trimethyltridecanoyl-CoA Homo sapiens alpha-hydroxyphytanoyl-CoA + succinate + CO2
-
?

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens
ATP
-
Rattus norvegicus
GTP
-
Homo sapiens
additional information UTP, CTP, ITP, AMP, ADP, NAD+ and FAD can not act as cofactors, ATP and GTP can be replaced by adenosine-5'-O-(3-thiotriphosphate), adenylylimidodiphosphate, adenylyl-(beta,gamma-methylene)-diphosphonate and guanylyl-imidodiphosphate Homo sapiens